Uncommon gnaq, MMP8, AKT3, EGFR, and PIK3R1 mutations in thyroid cancers

Avaniyapuram Kannan Murugan, Jianli Dong, Jingwu Xie, Mingzhao Xing

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Frequent mutations in the GNAQ, MMP8, Akt3, EGFR, and PIK3R1 genes have been reported in human cancers but mostly have not been well examined in thyroid cancer. Selected exons of GNAQ, MMP8, AKT3, EGFR, and PIK3R1 genes were sequenced in various thyroid cancers. We found a G2203A EGFR mutation, resulting in a G735S amino acid change, in one of 21 (5%) papillary thyroid cancer samples. We did not find any mutation in the MMP8 gene, but observed a frequent SNP A259G (K87E) genotype switch in various types of thyroid cancer samples. We did not find any mutation in the GNAQ, AKT3, and PIK3R1genes in various types of thyroid cancer. No mutation in these genes was found in 12 cell lines derived from various types of thyroid cancer. Therefore, unlike in other cancers, mutations in these genes are uncommon in thyroid cancer.

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
JournalEndocrine Pathology
Volume22
Issue number2
DOIs
StatePublished - Jun 1 2011

Keywords

  • AKT3
  • EGFR
  • GNAQ
  • MMP8
  • PIK3R1
  • Thyroid cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Fingerprint Dive into the research topics of 'Uncommon gnaq, MMP8, AKT3, EGFR, and PIK3R1 mutations in thyroid cancers'. Together they form a unique fingerprint.

Cite this