Uncovering a Novel Stone in 27 Patients: Calcium Tartrate Tetrahydrate

Colin Kleinguetl, James Williams, John C. Lieske, Michel Daudon, Marcelino E. Rivera, Paul J. Jannetto, Joshua Bornhorst, Denise Rokke, Erin T. Bird, James E. Lingeman, Marawan M. El Tayeb

Research output: Contribution to journalArticle

Abstract

Objective: To further analyze calcium tartrate tetrahydrate stones after a recent case report described this novel stone. Prior to this, there was only one previously reported occurrence of this stone in a human. This unusual stone composition is not tested for routinely. True prevalence and possible causes of this stone are unknown. Materials/Methods: During the previous case report, micro-CT and Fourier-transform infrared spectroscopy were used to identify a calcium tartrate tetrahydrate stone. This information was applied to urinary stones with previously unidentified compositions in the Mayo Metals laboratory database between 2010 and March 2018. Two additional stones were identified at our institution. Three patients had medical records available for analysis. Results: Between 2010 and March 2018, 35 calcium tartrate stones in 25 patients were identified in the Mayo database as well as 2 at our institution (37 stones in 27 patients). Thirty stones were pure calcium tartrate with the remainder having elements of more common stones. The average age was 46.3 (±14.7) with a slightly higher incidence in females (17 vs 10). Of the 3 medical records investigated, all 3 were males (average age 48.7), and each reported consumption of an energy supplement (Spark) routinely. Conclusion: The true prevalence of this relatively unknown stone remains unclear and additional investigation is warranted. We believe all stone laboratories should have access to the IR spectra for calcium tartrate tetrahydrate. Attention should be paid to possible causes of this stone, particularly with relation to oral supplements, to aid with future prevention and treatment.

Original languageEnglish (US)
JournalUrology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Medical Records
Databases
Urinary Calculi
Fourier Transform Infrared Spectroscopy
Metals
tartaric acid
Incidence
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Kleinguetl, C., Williams, J., Lieske, J. C., Daudon, M., Rivera, M. E., Jannetto, P. J., ... El Tayeb, M. M. (2019). Uncovering a Novel Stone in 27 Patients: Calcium Tartrate Tetrahydrate. Urology. https://doi.org/10.1016/j.urology.2019.01.005

Uncovering a Novel Stone in 27 Patients : Calcium Tartrate Tetrahydrate. / Kleinguetl, Colin; Williams, James; Lieske, John C.; Daudon, Michel; Rivera, Marcelino E.; Jannetto, Paul J.; Bornhorst, Joshua; Rokke, Denise; Bird, Erin T.; Lingeman, James E.; El Tayeb, Marawan M.

In: Urology, 01.01.2019.

Research output: Contribution to journalArticle

Kleinguetl, C, Williams, J, Lieske, JC, Daudon, M, Rivera, ME, Jannetto, PJ, Bornhorst, J, Rokke, D, Bird, ET, Lingeman, JE & El Tayeb, MM 2019, 'Uncovering a Novel Stone in 27 Patients: Calcium Tartrate Tetrahydrate', Urology. https://doi.org/10.1016/j.urology.2019.01.005
Kleinguetl, Colin ; Williams, James ; Lieske, John C. ; Daudon, Michel ; Rivera, Marcelino E. ; Jannetto, Paul J. ; Bornhorst, Joshua ; Rokke, Denise ; Bird, Erin T. ; Lingeman, James E. ; El Tayeb, Marawan M. / Uncovering a Novel Stone in 27 Patients : Calcium Tartrate Tetrahydrate. In: Urology. 2019.
@article{1e73143d19c94f82a053df2badf64017,
title = "Uncovering a Novel Stone in 27 Patients: Calcium Tartrate Tetrahydrate",
abstract = "Objective: To further analyze calcium tartrate tetrahydrate stones after a recent case report described this novel stone. Prior to this, there was only one previously reported occurrence of this stone in a human. This unusual stone composition is not tested for routinely. True prevalence and possible causes of this stone are unknown. Materials/Methods: During the previous case report, micro-CT and Fourier-transform infrared spectroscopy were used to identify a calcium tartrate tetrahydrate stone. This information was applied to urinary stones with previously unidentified compositions in the Mayo Metals laboratory database between 2010 and March 2018. Two additional stones were identified at our institution. Three patients had medical records available for analysis. Results: Between 2010 and March 2018, 35 calcium tartrate stones in 25 patients were identified in the Mayo database as well as 2 at our institution (37 stones in 27 patients). Thirty stones were pure calcium tartrate with the remainder having elements of more common stones. The average age was 46.3 (±14.7) with a slightly higher incidence in females (17 vs 10). Of the 3 medical records investigated, all 3 were males (average age 48.7), and each reported consumption of an energy supplement (Spark) routinely. Conclusion: The true prevalence of this relatively unknown stone remains unclear and additional investigation is warranted. We believe all stone laboratories should have access to the IR spectra for calcium tartrate tetrahydrate. Attention should be paid to possible causes of this stone, particularly with relation to oral supplements, to aid with future prevention and treatment.",
author = "Colin Kleinguetl and James Williams and Lieske, {John C.} and Michel Daudon and Rivera, {Marcelino E.} and Jannetto, {Paul J.} and Joshua Bornhorst and Denise Rokke and Bird, {Erin T.} and Lingeman, {James E.} and {El Tayeb}, {Marawan M.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.urology.2019.01.005",
language = "English (US)",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Uncovering a Novel Stone in 27 Patients

T2 - Calcium Tartrate Tetrahydrate

AU - Kleinguetl, Colin

AU - Williams, James

AU - Lieske, John C.

AU - Daudon, Michel

AU - Rivera, Marcelino E.

AU - Jannetto, Paul J.

AU - Bornhorst, Joshua

AU - Rokke, Denise

AU - Bird, Erin T.

AU - Lingeman, James E.

AU - El Tayeb, Marawan M.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objective: To further analyze calcium tartrate tetrahydrate stones after a recent case report described this novel stone. Prior to this, there was only one previously reported occurrence of this stone in a human. This unusual stone composition is not tested for routinely. True prevalence and possible causes of this stone are unknown. Materials/Methods: During the previous case report, micro-CT and Fourier-transform infrared spectroscopy were used to identify a calcium tartrate tetrahydrate stone. This information was applied to urinary stones with previously unidentified compositions in the Mayo Metals laboratory database between 2010 and March 2018. Two additional stones were identified at our institution. Three patients had medical records available for analysis. Results: Between 2010 and March 2018, 35 calcium tartrate stones in 25 patients were identified in the Mayo database as well as 2 at our institution (37 stones in 27 patients). Thirty stones were pure calcium tartrate with the remainder having elements of more common stones. The average age was 46.3 (±14.7) with a slightly higher incidence in females (17 vs 10). Of the 3 medical records investigated, all 3 were males (average age 48.7), and each reported consumption of an energy supplement (Spark) routinely. Conclusion: The true prevalence of this relatively unknown stone remains unclear and additional investigation is warranted. We believe all stone laboratories should have access to the IR spectra for calcium tartrate tetrahydrate. Attention should be paid to possible causes of this stone, particularly with relation to oral supplements, to aid with future prevention and treatment.

AB - Objective: To further analyze calcium tartrate tetrahydrate stones after a recent case report described this novel stone. Prior to this, there was only one previously reported occurrence of this stone in a human. This unusual stone composition is not tested for routinely. True prevalence and possible causes of this stone are unknown. Materials/Methods: During the previous case report, micro-CT and Fourier-transform infrared spectroscopy were used to identify a calcium tartrate tetrahydrate stone. This information was applied to urinary stones with previously unidentified compositions in the Mayo Metals laboratory database between 2010 and March 2018. Two additional stones were identified at our institution. Three patients had medical records available for analysis. Results: Between 2010 and March 2018, 35 calcium tartrate stones in 25 patients were identified in the Mayo database as well as 2 at our institution (37 stones in 27 patients). Thirty stones were pure calcium tartrate with the remainder having elements of more common stones. The average age was 46.3 (±14.7) with a slightly higher incidence in females (17 vs 10). Of the 3 medical records investigated, all 3 were males (average age 48.7), and each reported consumption of an energy supplement (Spark) routinely. Conclusion: The true prevalence of this relatively unknown stone remains unclear and additional investigation is warranted. We believe all stone laboratories should have access to the IR spectra for calcium tartrate tetrahydrate. Attention should be paid to possible causes of this stone, particularly with relation to oral supplements, to aid with future prevention and treatment.

UR - http://www.scopus.com/inward/record.url?scp=85060925866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060925866&partnerID=8YFLogxK

U2 - 10.1016/j.urology.2019.01.005

DO - 10.1016/j.urology.2019.01.005

M3 - Article

C2 - 30654140

AN - SCOPUS:85060925866

JO - Urology

JF - Urology

SN - 0090-4295

ER -