Undercut Cortex

Xiaoming Jin, Xingjie Ping

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Undercut cortex is a model of chronic posttraumatic epilepsy. The model is created by surgically cutting through the gray matter of a cortical region and the underneath white matter (undercut), so that the lesioned cortex is largely isolated from its neighboring cortex and subcortical structures. After a latency of at least 2 weeks following this initial lesion, epileptiform discharges can be recorded from brain slices in vitro, and electrical and behavior seizures can be observed in vivo in rodents, as well as cats, and monkeys. The model is efficient to prepare and highly reliable and reproducible, and mimics some key features of penetrating traumatic brain injury. In this chapter, we present an improved technique, using a simple custom-made surgical device for preparing this model in mice and rats, and discuss the application of this model in studying the mechanisms and prevention of posttraumatic epileptogenesis.

Original languageEnglish (US)
Title of host publicationModels of Seizures and Epilepsy
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages887-898
Number of pages12
ISBN (Print)9780128040669
DOIs
StatePublished - Jan 1 2017

Keywords

  • Electroencephalograph
  • Electrophysiology
  • Epileptogenesis
  • Homeostatic plasticity
  • Mice
  • Neocortex
  • Posttraumatic epilepsy
  • Rats
  • Spontaneous seizure

ASJC Scopus subject areas

  • Neuroscience(all)

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  • Cite this

    Jin, X., & Ping, X. (2017). Undercut Cortex. In Models of Seizures and Epilepsy: Second Edition (pp. 887-898). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-804066-9.00060-2