Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii - A Review

William Sullivan, Aaron T. Smith, Bradley R. Joyce

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Parasite differentiation from proliferating tachyzoites into latent bradyzoites is central to pathogenesis and transmission of the intracellular protozoan pathogen Toxoplasma gondii. The presence of bradyzoite-containing cysts in human hosts and their subsequent rupture can cause life-threatening recrudescence of acute infection in the immunocompromised and cyst formation in other animals contributes to zoonotic transmission and widespread dissemination of the parasite. In this review, we discuss the evidence showing how the clinically relevant process of bradyzoite differentiation is regulated at both transcriptional and post-transcriptional levels. Specific regulatory factors implicated in modulating bradyzoite differentiation include promoter-based cis-elements, epigenetic modifications and protein translation control through eukaryotic initiation factor -2 (eIF2). In addition to a summary of the current state of knowledge in these areas we discuss the pharmacological ramifications and pose some questions for future research.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalMemorias do Instituto Oswaldo Cruz
Volume104
Issue number2
StatePublished - Mar 2009

Fingerprint

Toxoplasma
Cysts
Parasites
Eukaryotic Initiation Factor-2
Zoonoses
Protein Biosynthesis
Epigenomics
Rupture
Pharmacology
Recurrence
Infection

Keywords

  • Apicomplexa
  • Bradyzoite
  • Development
  • Epigenetics
  • Parasite
  • Stress

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii - A Review. / Sullivan, William; Smith, Aaron T.; Joyce, Bradley R.

In: Memorias do Instituto Oswaldo Cruz, Vol. 104, No. 2, 03.2009, p. 155-161.

Research output: Contribution to journalArticle

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