Understanding the molecular genetics of renal cell neoplasia: Implications for diagnosis, prognosis and therapy

Liang Cheng, Sean R. Williamson, Shaobo Zhang, Gregory T. MacLennan, Rodolfo Montironi, Antonio Lopez-Beltran

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

Renal neoplasms exhibit a wide spectrum of molecular characteristics that are closely associated with their diverse morphologic manifestations and clinical behaviors. A wealth of information has been garnered via methodology ranging from classical cytogenetics to FISH and gene expression profiling; however, the exact mechanisms by which each type of renal tumor develops remain incompletely understood. Oddly, tumors with distinctly different morphology and prognosis sometimes show some overlap in the observed genetic abnormalities; by contrast, morphologically well characterized benign and malignant tumors that seem intuitively related cannot necessarily be shown to exhibit a step-wise progression from benign to malignant biologic behavior. Nevertheless, modern methodologies have been highly successful, not only in subclassifying renal tumors, but also in defining previously unrecognized entities. Further avenues of utility for these methods probably include the resolution of challenging differential diagnoses, as well as application in targeted therapy and prediction of outcome. We review the molecular and genetic characteristics of renal neoplasms, with emphasis on markers that demonstrate utility in differentiating morphologically similar neoplasms and in predicting clinical outcome.

Original languageEnglish (US)
Pages (from-to)843-864
Number of pages22
JournalExpert Review of Anticancer Therapy
Volume10
Issue number6
DOIs
StatePublished - Jun 1 2010

Keywords

  • Differential diagnosis
  • Gene expression profiling
  • Kidney classification
  • Molecular genetics
  • Molecular pathology
  • Renal neoplasm
  • Translocation RCC
  • Tumor origin

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

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