The α-globin of five black Americans, two Chinese, and five Filipinos with HbH disease (an α-thalassemia state in which there is a single functional α gene) were anlyzed by restriction endonuclease techniques. All sujects were found to have one chromosome 16, lacking both α genes, and another containing a single α gene (--/-α). Restriction endonuclease patterns of the DNA obtained from all 12 subjects were identical and compatible with unequal crossing-over as the mechanism of origin of the single α gene in these individuals.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Aug 18 1980|
ASJC Scopus subject areas
- Cell Biology