Unequal crossing-over: A common basis of single α-globin genes in Asians and American blacks with hemoglobin-H disease

J. A. Phillips, Terry Vik, A. F. Scott, K. E. Young, H. H. Kazazian, K. D. Smith, V. F. Fairbanks, H. M. Koenig

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The α-globin of five black Americans, two Chinese, and five Filipinos with HbH disease (an α-thalassemia state in which there is a single functional α gene) were anlyzed by restriction endonuclease techniques. All sujects were found to have one chromosome 16, lacking both α genes, and another containing a single α gene (--/-α). Restriction endonuclease patterns of the DNA obtained from all 12 subjects were identical and compatible with unequal crossing-over as the mechanism of origin of the single α gene in these individuals.

Original languageEnglish (US)
Pages (from-to)1066-1069
Number of pages4
JournalBlood
Volume55
Issue number6
StatePublished - 1980
Externally publishedYes

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Hemoglobin H
alpha-Thalassemia
Globins
Asian Americans
Genes
DNA Restriction Enzymes
Chromosomes, Human, Pair 16
Thalassemia
Chromosomes
DNA

ASJC Scopus subject areas

  • Hematology

Cite this

Phillips, J. A., Vik, T., Scott, A. F., Young, K. E., Kazazian, H. H., Smith, K. D., ... Koenig, H. M. (1980). Unequal crossing-over: A common basis of single α-globin genes in Asians and American blacks with hemoglobin-H disease. Blood, 55(6), 1066-1069.

Unequal crossing-over : A common basis of single α-globin genes in Asians and American blacks with hemoglobin-H disease. / Phillips, J. A.; Vik, Terry; Scott, A. F.; Young, K. E.; Kazazian, H. H.; Smith, K. D.; Fairbanks, V. F.; Koenig, H. M.

In: Blood, Vol. 55, No. 6, 1980, p. 1066-1069.

Research output: Contribution to journalArticle

Phillips, JA, Vik, T, Scott, AF, Young, KE, Kazazian, HH, Smith, KD, Fairbanks, VF & Koenig, HM 1980, 'Unequal crossing-over: A common basis of single α-globin genes in Asians and American blacks with hemoglobin-H disease', Blood, vol. 55, no. 6, pp. 1066-1069.
Phillips, J. A. ; Vik, Terry ; Scott, A. F. ; Young, K. E. ; Kazazian, H. H. ; Smith, K. D. ; Fairbanks, V. F. ; Koenig, H. M. / Unequal crossing-over : A common basis of single α-globin genes in Asians and American blacks with hemoglobin-H disease. In: Blood. 1980 ; Vol. 55, No. 6. pp. 1066-1069.
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