Unique cerebellar phenotype combining granule and Purkinje cell loss: Morphological evidence for weaver*pcd double mutant mice

Bernardino Ghetti, L. C. Triarhou, C. J. Alyea, Stephen Dlouhy, R. C. Karn

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Weaver (wv/wv) mutant mice lose most granule cells of the cerebellum during the first 2 weeks of postnatal life; 'Purkinje cell degeneration' (pcd/pcd) mutants lose virtually all Purkinje cells between postnatal days 17 and 45. Both these neurological mutations are autosomal recessive. We designed a breeding protocol that, in theory, should result in the production of mice with a doubly mutant, wv/wv*pcd/pcd, genotype. Some of the offspring of such crosses had a novel cerebellar phenotype in which both granule and Purkinje cells underwent degeneration, leading to a highly atrophic cortex. This phenotype is what would be expected in wv/wv*pcd/pcd double mutants, and the proportion of such progeny obtained fits with genetic expectations. We propose that (1)wv/wv*pcd/pcd double mutant mice are viable, and (2) the anatomical phenotype of such mice is a combined expression of the component phenotypes.

Original languageEnglish
Pages (from-to)27-38
Number of pages12
JournalJournal of Neurocytology
Volume20
Issue number1
DOIs
StatePublished - Jan 1991

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Purkinje Cells
Phenotype
Cerebellum
Breeding
Genotype
Mutation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Histology
  • Anatomy
  • Cell Biology

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Unique cerebellar phenotype combining granule and Purkinje cell loss : Morphological evidence for weaver*pcd double mutant mice. / Ghetti, Bernardino; Triarhou, L. C.; Alyea, C. J.; Dlouhy, Stephen; Karn, R. C.

In: Journal of Neurocytology, Vol. 20, No. 1, 01.1991, p. 27-38.

Research output: Contribution to journalArticle

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