United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU)

HaPanEU/UEG Working Group

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

Background: There have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years. In collaboration with United European Gastroenterology, the working group on ‘Harmonizing diagnosis and treatment of chronic pancreatitis across Europe’ (HaPanEU) developed these European guidelines using an evidence-based approach. Methods: Twelve multidisciplinary review groups performed systematic literature reviews to answer 101 predefined clinical questions. Recommendations were graded using the Grading of Recommendations Assessment, Development and Evaluation system and the answers were assessed by the entire group in a Delphi process online. The review groups presented their recommendations during the 2015 annual meeting of United European Gastroenterology. At this one-day, interactive conference, relevant remarks were voiced and overall agreement on each recommendation was quantified using plenary voting (Test and Evaluation Directorate). After a final round of adjustments based on these comments, a draft version was sent out to external reviewers. Results: The 101 recommendations covered 12 topics related to the clinical management of chronic pancreatitis: aetiology (working party (WP)1), diagnosis of chronic pancreatitis with imaging (WP2 and WP3), diagnosis of pancreatic exocrine insufficiency (WP4), surgery in chronic pancreatitis (WP5), medical therapy (WP6), endoscopic therapy (WP7), treatment of pancreatic pseudocysts (WP8), pancreatic pain (WP9), nutrition and malnutrition (WP10), diabetes mellitus (WP11) and the natural course of the disease and quality of life (WP12). Using the Grading of Recommendations Assessment, Development and Evaluation system, 70 of the 101 (70%) recommendations were rated as ‘strong' and plenary voting revealed ‘strong agreement' for 99 (98%) recommendations. Conclusions: The 2016 HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research.

Original languageEnglish (US)
Pages (from-to)153-199
Number of pages47
JournalUnited European Gastroenterology Journal
Volume5
Issue number2
DOIs
StatePublished - Mar 1 2017

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Chronic Pancreatitis
Gastroenterology
Guidelines
Politics
Therapeutics
Exocrine Pancreatic Insufficiency
Pancreatic Pseudocyst
Social Adjustment
Disease Management
Malnutrition
Publications
Diabetes Mellitus
Quality of Life
Pain
Research

Keywords

  • Chronic pancreatitis
  • Development and Evaluation
  • diabetes mellitus
  • endoscopic therapy
  • evidence-based
  • Grading of Recommendations Assessment
  • guidelines
  • pancreatic exocrine insufficiency

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU). / HaPanEU/UEG Working Group.

In: United European Gastroenterology Journal, Vol. 5, No. 2, 01.03.2017, p. 153-199.

Research output: Contribution to journalReview article

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title = "United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU)",
abstract = "Background: There have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years. In collaboration with United European Gastroenterology, the working group on ‘Harmonizing diagnosis and treatment of chronic pancreatitis across Europe’ (HaPanEU) developed these European guidelines using an evidence-based approach. Methods: Twelve multidisciplinary review groups performed systematic literature reviews to answer 101 predefined clinical questions. Recommendations were graded using the Grading of Recommendations Assessment, Development and Evaluation system and the answers were assessed by the entire group in a Delphi process online. The review groups presented their recommendations during the 2015 annual meeting of United European Gastroenterology. At this one-day, interactive conference, relevant remarks were voiced and overall agreement on each recommendation was quantified using plenary voting (Test and Evaluation Directorate). After a final round of adjustments based on these comments, a draft version was sent out to external reviewers. Results: The 101 recommendations covered 12 topics related to the clinical management of chronic pancreatitis: aetiology (working party (WP)1), diagnosis of chronic pancreatitis with imaging (WP2 and WP3), diagnosis of pancreatic exocrine insufficiency (WP4), surgery in chronic pancreatitis (WP5), medical therapy (WP6), endoscopic therapy (WP7), treatment of pancreatic pseudocysts (WP8), pancreatic pain (WP9), nutrition and malnutrition (WP10), diabetes mellitus (WP11) and the natural course of the disease and quality of life (WP12). Using the Grading of Recommendations Assessment, Development and Evaluation system, 70 of the 101 (70{\%}) recommendations were rated as ‘strong' and plenary voting revealed ‘strong agreement' for 99 (98{\%}) recommendations. Conclusions: The 2016 HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research.",
keywords = "Chronic pancreatitis, Development and Evaluation, diabetes mellitus, endoscopic therapy, evidence-based, Grading of Recommendations Assessment, guidelines, pancreatic exocrine insufficiency",
author = "{HaPanEU/UEG Working Group} and L{\"o}hr, {J. Matthias} and Enrique Dominguez-Munoz and Jonas Rosendahl and Marc Besselink and Julia Mayerle and Lerch, {Markus M.} and Stephan Haas and M. Akisik and Nikolaos Kartalis and Julio Iglesias-Garcia and Jutta Keller and Marja Boermeester and Jens Werner and Dumonceau, {Jean Marc} and Paul Fockens and Asbjorn Drewes and G{\"u}rlap Ceyhan and Bj{\"o}rn Lindkvist and Joost Drenth and Nils Ewald and Philip Hardt and {de Madaria}, Enrique and Heiko Witt and Alexander Schneider and Riccardo Manfredi and Br{\o}ndum, {Fr{\o}kjer J.} and Sasa Rudolf and Thomas Bollen and Marco Bruno",
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AU - HaPanEU/UEG Working Group

AU - Löhr, J. Matthias

AU - Dominguez-Munoz, Enrique

AU - Rosendahl, Jonas

AU - Besselink, Marc

AU - Mayerle, Julia

AU - Lerch, Markus M.

AU - Haas, Stephan

AU - Akisik, M.

AU - Kartalis, Nikolaos

AU - Iglesias-Garcia, Julio

AU - Keller, Jutta

AU - Boermeester, Marja

AU - Werner, Jens

AU - Dumonceau, Jean Marc

AU - Fockens, Paul

AU - Drewes, Asbjorn

AU - Ceyhan, Gürlap

AU - Lindkvist, Björn

AU - Drenth, Joost

AU - Ewald, Nils

AU - Hardt, Philip

AU - de Madaria, Enrique

AU - Witt, Heiko

AU - Schneider, Alexander

AU - Manfredi, Riccardo

AU - Brøndum, Frøkjer J.

AU - Rudolf, Sasa

AU - Bollen, Thomas

AU - Bruno, Marco

PY - 2017/3/1

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N2 - Background: There have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years. In collaboration with United European Gastroenterology, the working group on ‘Harmonizing diagnosis and treatment of chronic pancreatitis across Europe’ (HaPanEU) developed these European guidelines using an evidence-based approach. Methods: Twelve multidisciplinary review groups performed systematic literature reviews to answer 101 predefined clinical questions. Recommendations were graded using the Grading of Recommendations Assessment, Development and Evaluation system and the answers were assessed by the entire group in a Delphi process online. The review groups presented their recommendations during the 2015 annual meeting of United European Gastroenterology. At this one-day, interactive conference, relevant remarks were voiced and overall agreement on each recommendation was quantified using plenary voting (Test and Evaluation Directorate). After a final round of adjustments based on these comments, a draft version was sent out to external reviewers. Results: The 101 recommendations covered 12 topics related to the clinical management of chronic pancreatitis: aetiology (working party (WP)1), diagnosis of chronic pancreatitis with imaging (WP2 and WP3), diagnosis of pancreatic exocrine insufficiency (WP4), surgery in chronic pancreatitis (WP5), medical therapy (WP6), endoscopic therapy (WP7), treatment of pancreatic pseudocysts (WP8), pancreatic pain (WP9), nutrition and malnutrition (WP10), diabetes mellitus (WP11) and the natural course of the disease and quality of life (WP12). Using the Grading of Recommendations Assessment, Development and Evaluation system, 70 of the 101 (70%) recommendations were rated as ‘strong' and plenary voting revealed ‘strong agreement' for 99 (98%) recommendations. Conclusions: The 2016 HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research.

AB - Background: There have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years. In collaboration with United European Gastroenterology, the working group on ‘Harmonizing diagnosis and treatment of chronic pancreatitis across Europe’ (HaPanEU) developed these European guidelines using an evidence-based approach. Methods: Twelve multidisciplinary review groups performed systematic literature reviews to answer 101 predefined clinical questions. Recommendations were graded using the Grading of Recommendations Assessment, Development and Evaluation system and the answers were assessed by the entire group in a Delphi process online. The review groups presented their recommendations during the 2015 annual meeting of United European Gastroenterology. At this one-day, interactive conference, relevant remarks were voiced and overall agreement on each recommendation was quantified using plenary voting (Test and Evaluation Directorate). After a final round of adjustments based on these comments, a draft version was sent out to external reviewers. Results: The 101 recommendations covered 12 topics related to the clinical management of chronic pancreatitis: aetiology (working party (WP)1), diagnosis of chronic pancreatitis with imaging (WP2 and WP3), diagnosis of pancreatic exocrine insufficiency (WP4), surgery in chronic pancreatitis (WP5), medical therapy (WP6), endoscopic therapy (WP7), treatment of pancreatic pseudocysts (WP8), pancreatic pain (WP9), nutrition and malnutrition (WP10), diabetes mellitus (WP11) and the natural course of the disease and quality of life (WP12). Using the Grading of Recommendations Assessment, Development and Evaluation system, 70 of the 101 (70%) recommendations were rated as ‘strong' and plenary voting revealed ‘strong agreement' for 99 (98%) recommendations. Conclusions: The 2016 HaPanEU/United European Gastroenterology guidelines provide evidence-based recommendations concerning key aspects of the medical and surgical management of chronic pancreatitis based on current available evidence. These recommendations should serve as a reference standard for existing management of the disease and as a guide for future clinical research.

KW - Chronic pancreatitis

KW - Development and Evaluation

KW - diabetes mellitus

KW - endoscopic therapy

KW - evidence-based

KW - Grading of Recommendations Assessment

KW - guidelines

KW - pancreatic exocrine insufficiency

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