Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: On or off the trks?

Research output: Contribution to journalReview article

117 Scopus citations

Abstract

Nerve Growth Factor (NGF) is produced by and affects a number of immune and inflammatory cells. As part of the inflammatory response, NGF directly or indirectly alters the sensitivity of small diameter sensory neurons that communicate noxious information. The question remains as to the receptors and intracellular signaling cascades that mediate this sensitizing action of NGF. Although the general consensus is that NGF produces peripheral sensitization by activating TrkA, recent work suggests that p75 also contributes. Thus, both NGF receptors appear to contribute to peripheral sensitization although whether they act independently or together remains to be determined. Furthermore, controversy exists as to the downstream signaling pathways involved in NGF-induced peripheral sensitization.

Original languageEnglish (US)
Pages (from-to)26-41
Number of pages16
JournalMolecular Interventions
Volume7
Issue number1
DOIs
StatePublished - Feb 1 2007

ASJC Scopus subject areas

  • Molecular Medicine

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