Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells

David Ingram, Noel M. Caplice, Mervin Yoder

Research output: Contribution to journalArticle

372 Citations (Scopus)

Abstract

The field of vascular biology has been stimulated by the concept that circulating endothelial progenitor cells (EPCs) may play a role in neoangiogenesis (postnatal vasculogenesis). One problem for the field has been the difficulty in accurately defining an EPC. Likewise, circulating endothelial cells (CECs) are not well defined. The lack of a detailed understanding of the proliferative potential of EPCs and CECs has contributed to the controversy in identifying these cells and understanding their biology in vitro or in vivo. A novel paradigm using proliferative potential as one defining aspect of EPC biology suggests that a hierarchy of EPCs exists in human blood and blood vessels. The potential implications of this view in relation to current EPC definitions are discussed.

Original languageEnglish
Pages (from-to)1525-1531
Number of pages7
JournalBlood
Volume106
Issue number5
DOIs
StatePublished - Sep 1 2005

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Endothelial cells
Blood Vessels
Endothelial Cells
Cytology
Cell Biology
Endothelial Progenitor Cells
Blood vessels
Blood

ASJC Scopus subject areas

  • Hematology

Cite this

Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells. / Ingram, David; Caplice, Noel M.; Yoder, Mervin.

In: Blood, Vol. 106, No. 5, 01.09.2005, p. 1525-1531.

Research output: Contribution to journalArticle

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