Unsedated transnasal endoscopy with ultrathin endoscope as a screening tool for research studies

Robert M. Siwiec, Kulwinder Dua, Sri Naveen Surapaneni, Mohammed Hafeezullah, Benson Massey, Reza Shaker

Research output: Contribution to journalArticle

4 Scopus citations


Objectives/Hypothesis: Asymptomatic subjects volunteering for research studies are generally stratified as healthy based on a questionnaire, medical interviewing, and physical examination. The aim of this study was to evaluate the prevalence of upper gastrointestinal (GI) abnormalities in healthy asymptomatic volunteers using unsedated transnasal esophagogastroduodenoscopy (T-EGD) with an ultrathin endoscope as an additional screening tool. Study Design: A prospective study from one academic medical center with extensive experience in T-EGD. Methods: Consecutive 150 subjects volunteering for research studies were initially screened by using a gastroesophageal reflux disease (GERD) questionnaire, interviewing, and examination. Based on these, they were stratified as healthy asymptomatic volunteers or with GERD. Unsedated T-EGD was then performed by a faculty member who was blinded to the results of the initial assessment. Results: On initial assessment using GERD questionnaire, medical interviewing, and physical examination, of the total 150 consecutive research volunteers, 83 (average age 33 ± 16 years; 46 females, 37 males) subjects were healthy asymptomatic volunteers and 67 (average age 36 ± 15 years; 35 females, 32 males) had symptoms of GERD. On T-EGD, GI pathology was found in 15 of 83 (18%) healthy asymptomatic volunteers as compared to 24 of 67 (36%) stratified as having GERD (P <.01). The esophageal abnormalities found in healthy asymptomatic volunteers were esophagitis (13.3%), Barrett's esophagus (2.4%), hiatus hernia (2.4%), and gastritis (2.4%). Conclusions: A small but significant number of asymptomatic subjects have abnormal upper GI findings. Hence, transnasal unsedated endoscopy can be considered as a screening tool to stratify subjects as healthy, especially when considering them for research studies. Laryngoscope, 2012

Original languageEnglish (US)
Pages (from-to)1719-1723
Number of pages5
Issue number8
StatePublished - Aug 1 2012
Externally publishedYes


  • Barrett's esophagus
  • Transnasal endoscopy
  • gastroesophageal reflux disease
  • ultrathin endoscope
  • unsedated endoscopy

ASJC Scopus subject areas

  • Otorhinolaryngology

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