Unusual neoplasms detected in testicular cancer patients undergoing postchemotherapy retroperitoneal lymphadenectomy

J. S. Little, Richard Foster, Thomas Ulbright, J. P. Donohue

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Approximately 30% of patients with disseminated testicular cancer who receive platinum-based chemotherapy will experience normalization of tumor markers but have persistent, radiographically evident disease in the retroperitoneum. These patients are usually subjected to retroperitoneal lymph-node dissection (RPLND). In all, 45 of 557 patients (8.1%) undergoing postchemotherapy RPLND at Indiana University Medical Center (IUMC) were found to have neoplastic elements distinct from the classic germ-cell tumor types within their resected specimens. Examples included various sarcomas in 14 patients (3.7%), other nonsarcomatous non-germ-cell cancers in 18 patients (3.2%), and cystic atypical choriocarcinoma in 8 patients (1.4%). No distinct patient characteristic or histologic pattern in the primary tumor was predictive of these unusual findings in the RPLND specimen, although sampling error in the orchiectomy specimen could be the reason for this lack of correlation. Surgical resection of these chemoresistant tumors is potentially curative, with disease-free survival being obtained in 13 of 19 patients (68.4%) with sarcoma, 10 of 18 patients (55.6%) with nonsarcomatous cancers, and 7 of 8 patients (87.5%) with cystic atypical choriocarcinoma at mean follow-up intervals of 30.6, 42.5, and 24.7 months, respectively.

Original languageEnglish
Pages (from-to)200-206
Number of pages7
JournalWorld Journal of Urology
Volume12
Issue number4
DOIs
StatePublished - Aug 1994

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Testicular Neoplasms
Lymph Node Excision
Neoplasms
Choriocarcinoma
Sarcoma
Orchiectomy
Selection Bias
Germ Cell and Embryonal Neoplasms
Tumor Biomarkers
Platinum
Disease-Free Survival
Drug Therapy

ASJC Scopus subject areas

  • Urology

Cite this

Unusual neoplasms detected in testicular cancer patients undergoing postchemotherapy retroperitoneal lymphadenectomy. / Little, J. S.; Foster, Richard; Ulbright, Thomas; Donohue, J. P.

In: World Journal of Urology, Vol. 12, No. 4, 08.1994, p. 200-206.

Research output: Contribution to journalArticle

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