Unusual subtypes of prostate cancer

David J. Grignon

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations


The vast majority of prostatic tumors developing in adult males are adenocarcinomas. For the most part, variations in histology have not received specific designations and, from a practical approach, have had any specific prognostic implications handled through application of the Gleason grading system. Nonetheless, some of the adenocarcinoma variants have specific clinical features and differential diagnoses. Furthermore, there has been some controversy regarding the appropriate application of the Gleason grading scheme in these tumors. In addition, there are carcinomas that are in fact not adenocarcinomas and that should be kept as distinct entities. In this paper, the histologic variants of adenocarcinoma are reviewed with emphasis on clinicopathologic features and the clinical relevance of these subtypes. Other carcinomas that occur in the prostate gland are also discussed again with a focus on the clinicopathologic characteristics.

Original languageEnglish (US)
Pages (from-to)316-327
Number of pages12
JournalModern Pathology
Issue number3
StatePublished - Mar 2004


  • Adenocarcinoma
  • Basaloid carcinoma
  • Prostate gland
  • Small-cell carcinoma
  • Squamous cell carcinoma
  • Urothelial carcinoma
  • Variants

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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