Unusual thyroid constellation in Down syndrome: Congenital hypothyroidism, Graves' disease, and hemiagenesis in the same child

Research output: Contribution to journalArticle

8 Scopus citations


We report a girl with Down syndrome who was diagnosed with congenital hypothyroidism in the newborn period due to left thyroid hemiagenesis. Unexpectedly, her hypothyroidism resolved at the age of 3 years. After being off thyroid hormone replacement for 7 years and having normal thyroid function, she developed Graves' disease. Although Graves' disease in association with thyroid hemiagenesis has previously been reported, this represents the youngest patient in whom this scenario has been described. Issues pertaining to thyroid hemiagenesis, autoimmune hyperthyroidism, and thyroid disease in children with Down's syndrome are discussed.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalJournal of Pediatric Endocrinology and Metabolism
Issue number3
StatePublished - Mar 2009



  • Congenital hypothyroidism
  • Down syndrome
  • Graves' disease
  • Thyroid hemiagenesis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this