Unusual Voltage-Gated Sodium Currents as Targets for Pain

C. Barbosa, Theodore Cummins

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Pain is a serious health problem that impacts the lives of many individuals. Hyperexcitability of peripheral sensory neurons contributes to both acute and chronic pain syndromes. Because voltage-gated sodium currents are crucial to the transmission of electrical signals in peripheral sensory neurons, the channels that underlie these currents are attractive targets for pain therapeutics. Sodium currents and channels in peripheral sensory neurons are complex. Multiple-channel isoforms contribute to the macroscopic currents in nociceptive sensory neurons. These different isoforms exhibit substantial variations in their kinetics and pharmacology. Furthermore, sodium current complexity is enhanced by an array of interacting proteins that can substantially modify the properties of voltage-gated sodium channels. Resurgent sodium currents, atypical currents that can enhance recovery from inactivation and neuronal firing, are increasingly being recognized as playing potentially important roles in sensory neuron hyperexcitability and pain sensations. Here we discuss unusual sodium channels and currents that have been identified in nociceptive sensory neurons, describe what is known about the molecular determinants of the complex sodium currents in these neurons. Finally, we provide an overview of therapeutic strategies to target voltage-gated sodium currents in nociceptive neurons.

Original languageEnglish (US)
JournalCurrent Topics in Membranes
DOIs
StateAccepted/In press - 2016

Fingerprint

Sensory Receptor Cells
Sodium
Pain
Nociceptors
Sodium Channels
Protein Isoforms
Voltage-Gated Sodium Channels
Protein Array Analysis
Acute Pain
Chronic Pain
Pharmacology
Neurons
Health
Therapeutics

Keywords

  • Auxiliary subunits
  • Fibroblast growth factor homologous factor
  • Inflammation
  • Neuropathic
  • Pain
  • Resurgent currents
  • Sensory neurons
  • Voltage-gated sodium channels

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Unusual Voltage-Gated Sodium Currents as Targets for Pain. / Barbosa, C.; Cummins, Theodore.

In: Current Topics in Membranes, 2016.

Research output: Contribution to journalArticle

@article{2fa2d0bdbc154f8bb1192e23b3e10fc9,
title = "Unusual Voltage-Gated Sodium Currents as Targets for Pain",
abstract = "Pain is a serious health problem that impacts the lives of many individuals. Hyperexcitability of peripheral sensory neurons contributes to both acute and chronic pain syndromes. Because voltage-gated sodium currents are crucial to the transmission of electrical signals in peripheral sensory neurons, the channels that underlie these currents are attractive targets for pain therapeutics. Sodium currents and channels in peripheral sensory neurons are complex. Multiple-channel isoforms contribute to the macroscopic currents in nociceptive sensory neurons. These different isoforms exhibit substantial variations in their kinetics and pharmacology. Furthermore, sodium current complexity is enhanced by an array of interacting proteins that can substantially modify the properties of voltage-gated sodium channels. Resurgent sodium currents, atypical currents that can enhance recovery from inactivation and neuronal firing, are increasingly being recognized as playing potentially important roles in sensory neuron hyperexcitability and pain sensations. Here we discuss unusual sodium channels and currents that have been identified in nociceptive sensory neurons, describe what is known about the molecular determinants of the complex sodium currents in these neurons. Finally, we provide an overview of therapeutic strategies to target voltage-gated sodium currents in nociceptive neurons.",
keywords = "Auxiliary subunits, Fibroblast growth factor homologous factor, Inflammation, Neuropathic, Pain, Resurgent currents, Sensory neurons, Voltage-gated sodium channels",
author = "C. Barbosa and Theodore Cummins",
year = "2016",
doi = "10.1016/bs.ctm.2015.12.005",
language = "English (US)",
journal = "Current Topics in Membranes",
issn = "1063-5823",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Unusual Voltage-Gated Sodium Currents as Targets for Pain

AU - Barbosa, C.

AU - Cummins, Theodore

PY - 2016

Y1 - 2016

N2 - Pain is a serious health problem that impacts the lives of many individuals. Hyperexcitability of peripheral sensory neurons contributes to both acute and chronic pain syndromes. Because voltage-gated sodium currents are crucial to the transmission of electrical signals in peripheral sensory neurons, the channels that underlie these currents are attractive targets for pain therapeutics. Sodium currents and channels in peripheral sensory neurons are complex. Multiple-channel isoforms contribute to the macroscopic currents in nociceptive sensory neurons. These different isoforms exhibit substantial variations in their kinetics and pharmacology. Furthermore, sodium current complexity is enhanced by an array of interacting proteins that can substantially modify the properties of voltage-gated sodium channels. Resurgent sodium currents, atypical currents that can enhance recovery from inactivation and neuronal firing, are increasingly being recognized as playing potentially important roles in sensory neuron hyperexcitability and pain sensations. Here we discuss unusual sodium channels and currents that have been identified in nociceptive sensory neurons, describe what is known about the molecular determinants of the complex sodium currents in these neurons. Finally, we provide an overview of therapeutic strategies to target voltage-gated sodium currents in nociceptive neurons.

AB - Pain is a serious health problem that impacts the lives of many individuals. Hyperexcitability of peripheral sensory neurons contributes to both acute and chronic pain syndromes. Because voltage-gated sodium currents are crucial to the transmission of electrical signals in peripheral sensory neurons, the channels that underlie these currents are attractive targets for pain therapeutics. Sodium currents and channels in peripheral sensory neurons are complex. Multiple-channel isoforms contribute to the macroscopic currents in nociceptive sensory neurons. These different isoforms exhibit substantial variations in their kinetics and pharmacology. Furthermore, sodium current complexity is enhanced by an array of interacting proteins that can substantially modify the properties of voltage-gated sodium channels. Resurgent sodium currents, atypical currents that can enhance recovery from inactivation and neuronal firing, are increasingly being recognized as playing potentially important roles in sensory neuron hyperexcitability and pain sensations. Here we discuss unusual sodium channels and currents that have been identified in nociceptive sensory neurons, describe what is known about the molecular determinants of the complex sodium currents in these neurons. Finally, we provide an overview of therapeutic strategies to target voltage-gated sodium currents in nociceptive neurons.

KW - Auxiliary subunits

KW - Fibroblast growth factor homologous factor

KW - Inflammation

KW - Neuropathic

KW - Pain

KW - Resurgent currents

KW - Sensory neurons

KW - Voltage-gated sodium channels

UR - http://www.scopus.com/inward/record.url?scp=84961821084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961821084&partnerID=8YFLogxK

U2 - 10.1016/bs.ctm.2015.12.005

DO - 10.1016/bs.ctm.2015.12.005

M3 - Article

C2 - 27586296

AN - SCOPUS:84961821084

JO - Current Topics in Membranes

JF - Current Topics in Membranes

SN - 1063-5823

ER -