Update and critical appraisal of combined timolol and carbonic anhydrase inhibitors and the effect on ocular blood flow in glaucoma patients

Adam M. Moss, Alon Harris, Brent Siesky, Deepam Rusia, Kathleen M. Williamson, Yochai Shoshani

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Topical hypotensive therapy with both timolol and carbonic anhydrase inhibitors has been shown to be efficacious at reducing intraocular pressure. Many prospective studies have also suggested that carbonic anhydrase inhibitors augment ocular blood flow and vascular regulation independent of their hypotensive effects. Although consistent in their findings, these studies must be cautiously interpreted due to the limitations of study design and specific blood flow imaging modalities. The purpose of this review is to appraise and critically evaluate the current body of literature investigating the effects of combined treatment with topical carbonic anhydrase inhibitors and timolol in patients with glaucoma with respect to ocular blood flow, visual function, and optic nerve head structure.

Original languageEnglish (US)
Pages (from-to)233-241
Number of pages9
JournalClinical Ophthalmology
Volume4
Issue number1
StatePublished - Apr 30 2010

Keywords

  • Carbonic anhydrase inhibitor
  • Glaucoma
  • Ocular blood flow
  • Optic nerve head
  • Timolol
  • Visual function

ASJC Scopus subject areas

  • Ophthalmology

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