Update on diabetes mellitus

Murray Korc

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Diabetes mellitus is a complex multi-system disorder that may be classified as autoimmune mediated type 1 diabetes, or as insulin resistance associated type 2 diabetes. In type 1 diabetes, there is selective loss of the beta cells within the endocrine islets, as a consequence of T-cell and cytokine mediated destruction of these cells, perhaps in conjunction with destruction of the peri-islet Schwann cells. In type 2 diabetes, the etiology of the resistance ranges from post-receptor defects in the insulin signaling pathway to excessive production of adipocyte derived cytokines that antagonize insulin action to mitochondrial defects that interfere with glucose disposal. Proteome based technologies are providing new insights into these defects.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalDisease Markers
Volume20
Issue number3
DOIs
StatePublished - Jan 1 2004

Keywords

  • Beta cell
  • Insulin resistance
  • Mitochondrial defects
  • Pancreatic cancer

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Biochemistry, medical

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