Update on histopathological evaluation of lymphadenectomy specimens from prostate cancer patients

Alessandro Conti, Matteo Santoni, Luciano Burattini, Marina Scarpelli, Roberta Mazzucchelli, Andrea B. Galosi, Liang Cheng, Antonio Lopez-Beltran, Alberto Briganti, Francesco Montorsi, Rodolfo Montironi

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background: Metastases to lymph nodes (LNs) represent an unfavorable prognostic factor in patients with prostate cancer (PCa). Histological examination represents the gold standard in the evaluation of the lymphadenectomy (LND) specimens for the presence of secondary deposits. Methods and results: The metastatic detection rate can vary according to the approach adopted in the microscopic analysis of the LNs, which includes frozen-section examination, total inclusion of the tissue with and without whole-mount sections, serial sectioning, and the application of immunohistochemistry. The assessment of the sentinel LN, the search for micrometastases, and the evaluation of atypical LN metastatic sites further contribute to the detection of the metastatic spread. Conclusion: In this review, an update on the histopathological evaluation of LND specimens in patients with PCa is given, and focus is made on their clinical and prognostic significance.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalWorld Journal of Urology
DOIs
StateAccepted/In press - Dec 22 2015

Keywords

  • Lymph nodes
  • Metastases
  • Prostate cancer

ASJC Scopus subject areas

  • Urology

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    Conti, A., Santoni, M., Burattini, L., Scarpelli, M., Mazzucchelli, R., Galosi, A. B., Cheng, L., Lopez-Beltran, A., Briganti, A., Montorsi, F., & Montironi, R. (Accepted/In press). Update on histopathological evaluation of lymphadenectomy specimens from prostate cancer patients. World Journal of Urology, 1-10. https://doi.org/10.1007/s00345-015-1752-8