Update on Precocious Puberty in Girls

Research output: Contribution to journalReview article

Abstract

Precocious puberty (PP) in girls refers to secondary sexual development occurring earlier than the lower end of normal for the onset of puberty. It might be the presenting feature of a serious underlying condition or signify a common variation of normal for which no treatment is necessary. Depending on the source and type of sex steroids involved, clinical findings may indicate exposure to estrogens, androgens, or both. Likewise, the onset of the PP might be gradual or abrupt and the rate of progression is variable. Recent years have witnessed exciting advancements in the understanding of the molecular genetic basis for some forms of PP in girls as well as in the development of additional treatment options. In this review an update on the most commonly encountered causes of PP in girls including their clinical presentation, pathophysiology, diagnosis, and management are provided. Recommendations regarding when to refer, and areas in particular need of additional research are also delineated.

Original languageEnglish (US)
JournalJournal of Pediatric and Adolescent Gynecology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Precocious Puberty
Sexual Development
Puberty
Androgens
Molecular Biology
Estrogens
Steroids
Therapeutics
Research

Keywords

  • Etiologies
  • Girls
  • Pathophysiology
  • Precocious puberty

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Update on Precocious Puberty in Girls. / Eugster, Erica.

In: Journal of Pediatric and Adolescent Gynecology, 01.01.2019.

Research output: Contribution to journalReview article

@article{ab49e2c1cdb64b2a90dbbfe15ec042a8,
title = "Update on Precocious Puberty in Girls",
abstract = "Precocious puberty (PP) in girls refers to secondary sexual development occurring earlier than the lower end of normal for the onset of puberty. It might be the presenting feature of a serious underlying condition or signify a common variation of normal for which no treatment is necessary. Depending on the source and type of sex steroids involved, clinical findings may indicate exposure to estrogens, androgens, or both. Likewise, the onset of the PP might be gradual or abrupt and the rate of progression is variable. Recent years have witnessed exciting advancements in the understanding of the molecular genetic basis for some forms of PP in girls as well as in the development of additional treatment options. In this review an update on the most commonly encountered causes of PP in girls including their clinical presentation, pathophysiology, diagnosis, and management are provided. Recommendations regarding when to refer, and areas in particular need of additional research are also delineated.",
keywords = "Etiologies, Girls, Pathophysiology, Precocious puberty",
author = "Erica Eugster",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.jpag.2019.05.011",
language = "English (US)",
journal = "Journal of Pediatric and Adolescent Gynecology",
issn = "1083-3188",
publisher = "Elsevier USA",

}

TY - JOUR

T1 - Update on Precocious Puberty in Girls

AU - Eugster, Erica

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Precocious puberty (PP) in girls refers to secondary sexual development occurring earlier than the lower end of normal for the onset of puberty. It might be the presenting feature of a serious underlying condition or signify a common variation of normal for which no treatment is necessary. Depending on the source and type of sex steroids involved, clinical findings may indicate exposure to estrogens, androgens, or both. Likewise, the onset of the PP might be gradual or abrupt and the rate of progression is variable. Recent years have witnessed exciting advancements in the understanding of the molecular genetic basis for some forms of PP in girls as well as in the development of additional treatment options. In this review an update on the most commonly encountered causes of PP in girls including their clinical presentation, pathophysiology, diagnosis, and management are provided. Recommendations regarding when to refer, and areas in particular need of additional research are also delineated.

AB - Precocious puberty (PP) in girls refers to secondary sexual development occurring earlier than the lower end of normal for the onset of puberty. It might be the presenting feature of a serious underlying condition or signify a common variation of normal for which no treatment is necessary. Depending on the source and type of sex steroids involved, clinical findings may indicate exposure to estrogens, androgens, or both. Likewise, the onset of the PP might be gradual or abrupt and the rate of progression is variable. Recent years have witnessed exciting advancements in the understanding of the molecular genetic basis for some forms of PP in girls as well as in the development of additional treatment options. In this review an update on the most commonly encountered causes of PP in girls including their clinical presentation, pathophysiology, diagnosis, and management are provided. Recommendations regarding when to refer, and areas in particular need of additional research are also delineated.

KW - Etiologies

KW - Girls

KW - Pathophysiology

KW - Precocious puberty

UR - http://www.scopus.com/inward/record.url?scp=85068208680&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068208680&partnerID=8YFLogxK

U2 - 10.1016/j.jpag.2019.05.011

DO - 10.1016/j.jpag.2019.05.011

M3 - Review article

C2 - 31158483

AN - SCOPUS:85068208680

JO - Journal of Pediatric and Adolescent Gynecology

JF - Journal of Pediatric and Adolescent Gynecology

SN - 1083-3188

ER -