Update on the use of immunoglobulin in human disease: A review of evidence

Elena E. Perez, Jordan S. Orange, Francisco Bonilla, Javier Chinen, Ivan K. Chinn, Morna Dorsey, Yehia El-Gamal, Terry O. Harville, Elham Hossny, Bruce Mazer, Robert Nelson, Elizabeth Secord, Stanley C. Jordan, E. Richard Stiehm, Ashley A. Vo, Mark Ballow

Research output: Contribution to journalArticle

137 Scopus citations


Human immunoglobulin preparations for intravenous or subcutaneous administration are the cornerstone of treatment in patients with primary immunodeficiency diseases affecting the humoral immune system. Intravenous preparations have a number of important uses in the treatment of other diseases in humans as well, some for which acceptable treatment alternatives do not exist. We provide an update of the evidence-based guideline on immunoglobulin therapy, last published in 2006. Given the potential risks and inherent scarcity of human immunoglobulin, careful consideration of its indications and administration is warranted.

Original languageEnglish (US)
Pages (from-to)S1-S46
JournalJournal of Allergy and Clinical Immunology
Issue number3
StatePublished - Mar 1 2017


  • IGIV
  • IVIG
  • Immune globulin
  • SCIG
  • adverse events
  • autoimmunity
  • immune modulating
  • immunoglobulin
  • immunomodulation
  • primary immunodeficiency
  • transfusion

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Perez, E. E., Orange, J. S., Bonilla, F., Chinen, J., Chinn, I. K., Dorsey, M., El-Gamal, Y., Harville, T. O., Hossny, E., Mazer, B., Nelson, R., Secord, E., Jordan, S. C., Stiehm, E. R., Vo, A. A., & Ballow, M. (2017). Update on the use of immunoglobulin in human disease: A review of evidence. Journal of Allergy and Clinical Immunology, 139(3), S1-S46. https://doi.org/10.1016/j.jaci.2016.09.023