Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons

J. A. Black, Theodore Cummins, C. Plumpton, Y. H. Chen, W. Hormuzdiar, J. J. Clare, S. G. Waxman

Research output: Contribution to journalArticle

243 Citations (Scopus)

Abstract

After transection of their axons within the sciatic nerve, DRG neurons become hyperexcitable. Recent studies have demonstrated the emergence of a rapidly repriming tetrodotoxin (TTX)-sensitive sodium current that may account for this hyperexcitability in axotomized small (

Original languageEnglish (US)
Pages (from-to)2776-2785
Number of pages10
JournalJournal of Neurophysiology
Volume82
Issue number5
StatePublished - 1999
Externally publishedYes

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Sodium Channels
Diagnosis-Related Groups
Tetrodotoxin
Sciatic Nerve
Axons
Up-Regulation
Sodium
Neurons
Wounds and Injuries

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Black, J. A., Cummins, T., Plumpton, C., Chen, Y. H., Hormuzdiar, W., Clare, J. J., & Waxman, S. G. (1999). Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons. Journal of Neurophysiology, 82(5), 2776-2785.

Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons. / Black, J. A.; Cummins, Theodore; Plumpton, C.; Chen, Y. H.; Hormuzdiar, W.; Clare, J. J.; Waxman, S. G.

In: Journal of Neurophysiology, Vol. 82, No. 5, 1999, p. 2776-2785.

Research output: Contribution to journalArticle

Black, JA, Cummins, T, Plumpton, C, Chen, YH, Hormuzdiar, W, Clare, JJ & Waxman, SG 1999, 'Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons', Journal of Neurophysiology, vol. 82, no. 5, pp. 2776-2785.
Black, J. A. ; Cummins, Theodore ; Plumpton, C. ; Chen, Y. H. ; Hormuzdiar, W. ; Clare, J. J. ; Waxman, S. G. / Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons. In: Journal of Neurophysiology. 1999 ; Vol. 82, No. 5. pp. 2776-2785.
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