Upregulation of type I interleukin-1 receptor after traumatic spinal cord injury in adult rats

Xiao Fei Wang, Li Dong Huang, Pan Pan Yu, Jian Guo Hu, Lan Yin, Li Wang, Xiao-Ming Xu, Pei Hua Lu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Post-traumatic inflammation response has been implicated in secondary injury mechanisms after spinal cord injury (SCI). Interleukin-1 (IL-1) is a key inflammatory mediator that is increasingly expressed after SCI. The action of IL-1 is mediated through its functional receptor, type I interleukin-1 receptor (IL-1RI). However, whether this receptor is expressed after SCI remains to be elucidated. In the present study, the temporospatial expression of IL-1RI was detected in rats that received a moderate contusive SCI (a 10 g rod dropped at a height of 12.5 mm) at the ninth to tenth thoracic vertebral level using a widely used New York University impact device. Our study demonstrated that IL-1RI was slightly increased at 4 h post-injury compared to the normal or sham-operated controls, reached the peak at 8 h at mRNA level (4.44-fold, P

Original languageEnglish (US)
Pages (from-to)220-228
Number of pages9
JournalActa Neuropathologica
Volume111
Issue number3
DOIs
StatePublished - Mar 2006
Externally publishedYes

Fingerprint

Interleukin-1 Type I Receptors
Spinal Cord Injuries
Up-Regulation
Interleukin-1
Wounds and Injuries
Thorax
Inflammation
Equipment and Supplies
Messenger RNA

Keywords

  • IL-1
  • IL-1 receptor
  • Inflammation
  • Spinalcord injury rat

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Wang, X. F., Huang, L. D., Yu, P. P., Hu, J. G., Yin, L., Wang, L., ... Lu, P. H. (2006). Upregulation of type I interleukin-1 receptor after traumatic spinal cord injury in adult rats. Acta Neuropathologica, 111(3), 220-228. https://doi.org/10.1007/s00401-005-0016-x

Upregulation of type I interleukin-1 receptor after traumatic spinal cord injury in adult rats. / Wang, Xiao Fei; Huang, Li Dong; Yu, Pan Pan; Hu, Jian Guo; Yin, Lan; Wang, Li; Xu, Xiao-Ming; Lu, Pei Hua.

In: Acta Neuropathologica, Vol. 111, No. 3, 03.2006, p. 220-228.

Research output: Contribution to journalArticle

Wang, Xiao Fei ; Huang, Li Dong ; Yu, Pan Pan ; Hu, Jian Guo ; Yin, Lan ; Wang, Li ; Xu, Xiao-Ming ; Lu, Pei Hua. / Upregulation of type I interleukin-1 receptor after traumatic spinal cord injury in adult rats. In: Acta Neuropathologica. 2006 ; Vol. 111, No. 3. pp. 220-228.
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