Upstream open reading frames differentially regulate genespecific translation in the integrated stress response

Sara K. Young, Ronald Wek

Research output: Contribution to journalReview article

93 Scopus citations

Abstract

Translation regulation largely occurs during initiation, which features ribosome assembly onto mRNAs and selection of the translation start site. Short, upstream ORFs (uORFs) located in the 5 -leader of the mRNA can be selected for translation. Multiple transcripts associated with stress amelioration are preferentially translated through uORF-mediated mechanisms during activation of the integrated stress response (ISR) in which phosphorylation of the α subunit of eIF2 results in a coincident global reduction in translation initiation. This review presents key features of uORFs that serve to optimize translational control that is essential for regulation of cell fate in response to environmental stresses.

Original languageEnglish (US)
Pages (from-to)16927-16935
Number of pages9
JournalJournal of Biological Chemistry
Volume291
Issue number33
DOIs
StatePublished - Aug 12 2016

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Molecular Biology
  • Cell Biology

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