Uptake of 2-deoxy, 2-(18F) fluoro-D-glucose in bladder cancer

Animal localization and initial patient positron emission tomography

J. V. Harney, R. L. Wahl, M. Liebert, D. E. Kuhl, Gary Hutchins, G. Wedemeyer, H. B. Grossman

Research output: Contribution to journalArticle

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Abstract

An orthotopically transplanted, locally metastasizing rat bladder tumor model was developed to evaluate the extent of uptake of fluoro-deoxy-glucose (FDG) in bladder cancer. Significant uptake of FDG in localized bladder tumors in rats was shown, with an average tumor-to-blood ratio of 39 at 2 hours after intravenous FDG administration. Metastases (3 nodal and 1 peritoneal) also showed significant uptake of FDG, with an average metastasis-to-blood ratio of 21.7, and tumor involved-to-normal lymph node ratio of 5.3. Because FDG is excreted in the urine, urinary FDG potentially could prevent the use of FDG/positron emission tomography (FDG/PET) scanning for localized bladder cancer. Bladder lavage successfully reduced the retention of FDG in the normal rat bladder, with an estimated uptake ratio of tumor-to-normal bladder of 13.1 after 5 ml. saline irrigation. Based on these data, we performed an FDG/PET scan of a patient with biopsy proved recurrent intravesical bladder cancer after radiation therapy. Computerized tomography (CT) of the pelvis showed abnormalities consistent with radiation scarring and extravesical tumor. Due to the scarring, the extent of tumor growth could not be determined. The patient also had pulmonary opacities seen on chest radiography. The FDG/PET scan of this patient showed significant extravesical uptake in the pelvis, confirming the abnormality noted on CT. Good images of the clinically apparent metastases in the chest also were obtained. These preliminary data indicate that FDG/PET imaging of bladder cancer is feasible and it may provide new information for the diagnosis and staging of patients with bladder cancer.

Original languageEnglish (US)
Pages (from-to)279-283
Number of pages5
JournalJournal of Urology
Volume145
Issue number2
StatePublished - 1991
Externally publishedYes

Fingerprint

Fluorodeoxyglucose F18
Urinary Bladder Neoplasms
Positron-Emission Tomography
Glucose
Urinary Bladder
Neoplasms
Neoplasm Metastasis
Pelvis
Cicatrix
Thorax
Tomography
Therapeutic Irrigation
Radiography
Radiotherapy
Lymph Nodes
Urine
Radiation
Biopsy
Lung

Keywords

  • Bladder neoplasms
  • Emission computed
  • Tomography

ASJC Scopus subject areas

  • Urology

Cite this

Harney, J. V., Wahl, R. L., Liebert, M., Kuhl, D. E., Hutchins, G., Wedemeyer, G., & Grossman, H. B. (1991). Uptake of 2-deoxy, 2-(18F) fluoro-D-glucose in bladder cancer: Animal localization and initial patient positron emission tomography. Journal of Urology, 145(2), 279-283.

Uptake of 2-deoxy, 2-(18F) fluoro-D-glucose in bladder cancer : Animal localization and initial patient positron emission tomography. / Harney, J. V.; Wahl, R. L.; Liebert, M.; Kuhl, D. E.; Hutchins, Gary; Wedemeyer, G.; Grossman, H. B.

In: Journal of Urology, Vol. 145, No. 2, 1991, p. 279-283.

Research output: Contribution to journalArticle

Harney, JV, Wahl, RL, Liebert, M, Kuhl, DE, Hutchins, G, Wedemeyer, G & Grossman, HB 1991, 'Uptake of 2-deoxy, 2-(18F) fluoro-D-glucose in bladder cancer: Animal localization and initial patient positron emission tomography', Journal of Urology, vol. 145, no. 2, pp. 279-283.
Harney, J. V. ; Wahl, R. L. ; Liebert, M. ; Kuhl, D. E. ; Hutchins, Gary ; Wedemeyer, G. ; Grossman, H. B. / Uptake of 2-deoxy, 2-(18F) fluoro-D-glucose in bladder cancer : Animal localization and initial patient positron emission tomography. In: Journal of Urology. 1991 ; Vol. 145, No. 2. pp. 279-283.
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