Abstract
The neurologic manifestations of renal failure are variable, nonspecific and most likely result from multiple metabolic derangements. Commonly used neurodiagnostic tests may be abnormal but are generally nondiagnostic. The EEG, although nonspecific, correlates with clinical symptoms and may be of diagnostic value if serial studies are performed. The pathophysiology of uremic encephalopathy is not well understood and multiple potential 'uremic toxins' have been evaluated. Of these, parathyroid hormone is the only substance to be clearly linked to clinical findings. It is likely that other, even unidentified toxins, may play a role in the complex pathogenesis of neurologic disease associated with renal failure.
| Original language | English |
|---|---|
| Pages (from-to) | 251-256 |
| Number of pages | 6 |
| Journal | Clinical Nephrology |
| Volume | 42 |
| Issue number | 4 |
| State | Published - 1994 |
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Keywords
- Cognitive function
- Electroencephalogram
- Kidney diseases
- Neurotoxin
- Parathyroid hormone
ASJC Scopus subject areas
- Nephrology
Cite this
Uremic encephalopathy. / Moe, Sharon; Sprague, S. M.
In: Clinical Nephrology, Vol. 42, No. 4, 1994, p. 251-256.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Uremic encephalopathy
AU - Moe, Sharon
AU - Sprague, S. M.
PY - 1994
Y1 - 1994
N2 - The neurologic manifestations of renal failure are variable, nonspecific and most likely result from multiple metabolic derangements. Commonly used neurodiagnostic tests may be abnormal but are generally nondiagnostic. The EEG, although nonspecific, correlates with clinical symptoms and may be of diagnostic value if serial studies are performed. The pathophysiology of uremic encephalopathy is not well understood and multiple potential 'uremic toxins' have been evaluated. Of these, parathyroid hormone is the only substance to be clearly linked to clinical findings. It is likely that other, even unidentified toxins, may play a role in the complex pathogenesis of neurologic disease associated with renal failure.
AB - The neurologic manifestations of renal failure are variable, nonspecific and most likely result from multiple metabolic derangements. Commonly used neurodiagnostic tests may be abnormal but are generally nondiagnostic. The EEG, although nonspecific, correlates with clinical symptoms and may be of diagnostic value if serial studies are performed. The pathophysiology of uremic encephalopathy is not well understood and multiple potential 'uremic toxins' have been evaluated. Of these, parathyroid hormone is the only substance to be clearly linked to clinical findings. It is likely that other, even unidentified toxins, may play a role in the complex pathogenesis of neurologic disease associated with renal failure.
KW - Cognitive function
KW - Electroencephalogram
KW - Kidney diseases
KW - Neurotoxin
KW - Parathyroid hormone
UR - http://www.scopus.com/inward/record.url?scp=0028006841&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028006841&partnerID=8YFLogxK
M3 - Article
VL - 42
SP - 251
EP - 256
JO - Clinical Nephrology
JF - Clinical Nephrology
SN - 0301-0430
IS - 4
ER -