Uremic vascular calcification

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Recent evidence suggests that uremic vascular calcification is an active, cell-mediated process resembling osteogenesis in bone rather than passive precipitation. We identified increased expression of bone-associated proteins (osteopontin, bone sialoprotein, alkaline phosphatase, type I collagen) and the bone-specific transcription factor core-binding factor α1 (Cbfα1) in histologic sections of inferior epigastric arteries obtained from patients with stage V chronic kidney disease or calcific uremic arteriolopathy. In in vitro experiments, the addition of uremic serum to cultured vascular smooth muscle cells up-regulated osteopontin and Cbfα1 expression and accelerated mineralization. This implies that the uremic mileau may lead to dedifferentiation of vascular smooth muscle cells, with subsequent mineralization. However, a lack of inhibitors of calcification may also be important. Dialysis patients with low levels of serum fetuin A, a circulating inhibitor of mineralization, have increased coronary artery calcification, and fetuin A can inhibit mineralization of vascular smooth muscle cells in vitro. Further understanding of the pathophysiology of uremic vascular calcification is needed to design effective therapeutic strategies to intervene with this devastating condition in patients with stage V chronic kidney disease.

Original languageEnglish
Pages (from-to)380-384
Number of pages5
JournalJournal of Investigative Medicine
Volume54
Issue number7
DOIs
StatePublished - Nov 2006

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Vascular Calcification
Core Binding Factors
alpha-2-HS-Glycoprotein
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Bone
Osteopontin
Cells
Chronic Renal Insufficiency
Bone and Bones
Epigastric Arteries
Integrin-Binding Sialoprotein
Dialysis
Collagen Type I
Serum
Osteogenesis
Alkaline Phosphatase
Coronary Vessels
Transcription Factors

Keywords

  • Core-binding factor α
  • Dialysis
  • Vascular calcification

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Uremic vascular calcification. / Chen, Xuening (Neal); Moe, Sharon.

In: Journal of Investigative Medicine, Vol. 54, No. 7, 11.2006, p. 380-384.

Research output: Contribution to journalArticle

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