Uremic vasculopathy

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Recent evidence suggests that uremic vascular calcification is an active cell-mediated process resembling osteogenesis in bone rather than passive precipitation. We have identified increased expression of bone-associated proteins (osteopontin, bone sialoprotein, alkaline phosphatase, type I collagen), and the bone-specific transcription factor core-binding factor α-1 (Cbfa1) in histologic sections of inferior epigastric arteries obtained from patients with end-stage renal disease (ESRD) or calcific uremic arteriolopathy. In in vitro experiments, the addition of uremic serum to cultured vascular smooth muscle cells up-regulated osteopontin and Cbfa1 expression and accelerated mineralization. This implies that the uremic milieu may lead to dedifferentiation of vascular smooth muscle cells with subsequent mineralization. Further understanding of the pathophysiology of uremic vascular calcification is needed to design effective therapeutic strategies to intervene with this devastating condition in ESRD patients.

Original languageEnglish (US)
Pages (from-to)413-416
Number of pages4
JournalSeminars in nephrology
Volume24
Issue number5
DOIs
StatePublished - Sep 1 2004

Keywords

  • bone
  • calcific uremic arteriolopathy
  • dialysis
  • vascular calcification

ASJC Scopus subject areas

  • Nephrology

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