Urinary 1-hydroxypyrene and 2-naphthol concentrations in male Koreans

H. Kim, S. H. Cho, J. W. Kang, Y. D. Kim, Hongmei Nan, C. H. Lee, H. Lee, T. Kawamoto

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Objective: Urinary 1-hydroxypyrene (1-OHP) has been used as a biological marker of exposure to polycyclic aromatic hydrocarbons (PAHs), and urinary 2-naphthol is suggested as a new marker for route-specific exposure to airborne PAHs. We analyzed urinary 1-OHP and 2-naphthol concentrations in 292 male Koreans (129 university students and 163 shipyard workers) to define the distribution pattern in Koreans with no or low occupational exposure to PAHs. Method: Histories of cigarette smoking and the eating of PAH-containing foods were obtained by a self-administered structured questionnaire. Urine samples were collected and urinary 1-OHP and 2-naphthol concentrations were measured using high-performance liquid chromatography (HPLC). Results: The arithmetic (geometric) means of urinary 1-OHP and 2-naphthol concentrations for all students, expressed as micromoles per mole of creatinine, were 0.04 (0.04) and 3.12 (2.22), for non-smokers 0.03 (0.03) and 1.78 (1.30) and for smokers 0.05 (0.03) and 4.36 (3.62), respectively. Among shipyard workers, the arithmetic (geometric) means of urinary 1-OHP and 2-naphthol concentrations were 0.69 (0.31) and 4.37 (2.62) for all, 0.27 (0.18) and 2.46 (1.16) for non-smokers, and 0.97 (0.44) and 5.60 (4.44) for smokers, respectively. Mean urinary 1-OHP and 2-naphthol concentrations differed significantly between non-smokers and smokers both in students and in shipyard workers. In smokers, some variables related to smoking habit were positively correlated with urinary 1-OHP and with 2-naphthol concentrations. The latter showed better correlations with the variables related to smoking amount than the former. None of the food-related factors was significantly correlated with urinary 1-OHP or 2-naphthol concentration. Conclusion: These results suggest that urinary 2-naphthol concentration is more sensitively affected by smoking status than urinary 1-OHP concentration and that urinary 2-naphthol is a sensitive marker for low-level inhalation of PAHs.

Original languageEnglish (US)
Pages (from-to)59-62
Number of pages4
JournalInternational Archives of Occupational and Environmental Health
Volume74
Issue number1
DOIs
StatePublished - Feb 19 2001
Externally publishedYes

Fingerprint

Polycyclic Aromatic Hydrocarbons
Smoking
Students
2-naphthol
Food
Occupational Exposure
Inhalation
Habits
Creatinine
Eating
Biomarkers
High Pressure Liquid Chromatography
Urine

Keywords

  • 1-Hydroxypyrene
  • 2-Naphthol
  • Korean

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Urinary 1-hydroxypyrene and 2-naphthol concentrations in male Koreans. / Kim, H.; Cho, S. H.; Kang, J. W.; Kim, Y. D.; Nan, Hongmei; Lee, C. H.; Lee, H.; Kawamoto, T.

In: International Archives of Occupational and Environmental Health, Vol. 74, No. 1, 19.02.2001, p. 59-62.

Research output: Contribution to journalArticle

Kim, H. ; Cho, S. H. ; Kang, J. W. ; Kim, Y. D. ; Nan, Hongmei ; Lee, C. H. ; Lee, H. ; Kawamoto, T. / Urinary 1-hydroxypyrene and 2-naphthol concentrations in male Koreans. In: International Archives of Occupational and Environmental Health. 2001 ; Vol. 74, No. 1. pp. 59-62.
@article{6b91fb97bd06401b805111a764240a57,
title = "Urinary 1-hydroxypyrene and 2-naphthol concentrations in male Koreans",
abstract = "Objective: Urinary 1-hydroxypyrene (1-OHP) has been used as a biological marker of exposure to polycyclic aromatic hydrocarbons (PAHs), and urinary 2-naphthol is suggested as a new marker for route-specific exposure to airborne PAHs. We analyzed urinary 1-OHP and 2-naphthol concentrations in 292 male Koreans (129 university students and 163 shipyard workers) to define the distribution pattern in Koreans with no or low occupational exposure to PAHs. Method: Histories of cigarette smoking and the eating of PAH-containing foods were obtained by a self-administered structured questionnaire. Urine samples were collected and urinary 1-OHP and 2-naphthol concentrations were measured using high-performance liquid chromatography (HPLC). Results: The arithmetic (geometric) means of urinary 1-OHP and 2-naphthol concentrations for all students, expressed as micromoles per mole of creatinine, were 0.04 (0.04) and 3.12 (2.22), for non-smokers 0.03 (0.03) and 1.78 (1.30) and for smokers 0.05 (0.03) and 4.36 (3.62), respectively. Among shipyard workers, the arithmetic (geometric) means of urinary 1-OHP and 2-naphthol concentrations were 0.69 (0.31) and 4.37 (2.62) for all, 0.27 (0.18) and 2.46 (1.16) for non-smokers, and 0.97 (0.44) and 5.60 (4.44) for smokers, respectively. Mean urinary 1-OHP and 2-naphthol concentrations differed significantly between non-smokers and smokers both in students and in shipyard workers. In smokers, some variables related to smoking habit were positively correlated with urinary 1-OHP and with 2-naphthol concentrations. The latter showed better correlations with the variables related to smoking amount than the former. None of the food-related factors was significantly correlated with urinary 1-OHP or 2-naphthol concentration. Conclusion: These results suggest that urinary 2-naphthol concentration is more sensitively affected by smoking status than urinary 1-OHP concentration and that urinary 2-naphthol is a sensitive marker for low-level inhalation of PAHs.",
keywords = "1-Hydroxypyrene, 2-Naphthol, Korean",
author = "H. Kim and Cho, {S. H.} and Kang, {J. W.} and Kim, {Y. D.} and Hongmei Nan and Lee, {C. H.} and H. Lee and T. Kawamoto",
year = "2001",
month = "2",
day = "19",
doi = "10.1007/s004200000193",
language = "English (US)",
volume = "74",
pages = "59--62",
journal = "International Archives of Occupational and Environmental Health",
issn = "0340-0131",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Urinary 1-hydroxypyrene and 2-naphthol concentrations in male Koreans

AU - Kim, H.

AU - Cho, S. H.

AU - Kang, J. W.

AU - Kim, Y. D.

AU - Nan, Hongmei

AU - Lee, C. H.

AU - Lee, H.

AU - Kawamoto, T.

PY - 2001/2/19

Y1 - 2001/2/19

N2 - Objective: Urinary 1-hydroxypyrene (1-OHP) has been used as a biological marker of exposure to polycyclic aromatic hydrocarbons (PAHs), and urinary 2-naphthol is suggested as a new marker for route-specific exposure to airborne PAHs. We analyzed urinary 1-OHP and 2-naphthol concentrations in 292 male Koreans (129 university students and 163 shipyard workers) to define the distribution pattern in Koreans with no or low occupational exposure to PAHs. Method: Histories of cigarette smoking and the eating of PAH-containing foods were obtained by a self-administered structured questionnaire. Urine samples were collected and urinary 1-OHP and 2-naphthol concentrations were measured using high-performance liquid chromatography (HPLC). Results: The arithmetic (geometric) means of urinary 1-OHP and 2-naphthol concentrations for all students, expressed as micromoles per mole of creatinine, were 0.04 (0.04) and 3.12 (2.22), for non-smokers 0.03 (0.03) and 1.78 (1.30) and for smokers 0.05 (0.03) and 4.36 (3.62), respectively. Among shipyard workers, the arithmetic (geometric) means of urinary 1-OHP and 2-naphthol concentrations were 0.69 (0.31) and 4.37 (2.62) for all, 0.27 (0.18) and 2.46 (1.16) for non-smokers, and 0.97 (0.44) and 5.60 (4.44) for smokers, respectively. Mean urinary 1-OHP and 2-naphthol concentrations differed significantly between non-smokers and smokers both in students and in shipyard workers. In smokers, some variables related to smoking habit were positively correlated with urinary 1-OHP and with 2-naphthol concentrations. The latter showed better correlations with the variables related to smoking amount than the former. None of the food-related factors was significantly correlated with urinary 1-OHP or 2-naphthol concentration. Conclusion: These results suggest that urinary 2-naphthol concentration is more sensitively affected by smoking status than urinary 1-OHP concentration and that urinary 2-naphthol is a sensitive marker for low-level inhalation of PAHs.

AB - Objective: Urinary 1-hydroxypyrene (1-OHP) has been used as a biological marker of exposure to polycyclic aromatic hydrocarbons (PAHs), and urinary 2-naphthol is suggested as a new marker for route-specific exposure to airborne PAHs. We analyzed urinary 1-OHP and 2-naphthol concentrations in 292 male Koreans (129 university students and 163 shipyard workers) to define the distribution pattern in Koreans with no or low occupational exposure to PAHs. Method: Histories of cigarette smoking and the eating of PAH-containing foods were obtained by a self-administered structured questionnaire. Urine samples were collected and urinary 1-OHP and 2-naphthol concentrations were measured using high-performance liquid chromatography (HPLC). Results: The arithmetic (geometric) means of urinary 1-OHP and 2-naphthol concentrations for all students, expressed as micromoles per mole of creatinine, were 0.04 (0.04) and 3.12 (2.22), for non-smokers 0.03 (0.03) and 1.78 (1.30) and for smokers 0.05 (0.03) and 4.36 (3.62), respectively. Among shipyard workers, the arithmetic (geometric) means of urinary 1-OHP and 2-naphthol concentrations were 0.69 (0.31) and 4.37 (2.62) for all, 0.27 (0.18) and 2.46 (1.16) for non-smokers, and 0.97 (0.44) and 5.60 (4.44) for smokers, respectively. Mean urinary 1-OHP and 2-naphthol concentrations differed significantly between non-smokers and smokers both in students and in shipyard workers. In smokers, some variables related to smoking habit were positively correlated with urinary 1-OHP and with 2-naphthol concentrations. The latter showed better correlations with the variables related to smoking amount than the former. None of the food-related factors was significantly correlated with urinary 1-OHP or 2-naphthol concentration. Conclusion: These results suggest that urinary 2-naphthol concentration is more sensitively affected by smoking status than urinary 1-OHP concentration and that urinary 2-naphthol is a sensitive marker for low-level inhalation of PAHs.

KW - 1-Hydroxypyrene

KW - 2-Naphthol

KW - Korean

UR - http://www.scopus.com/inward/record.url?scp=0035140678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035140678&partnerID=8YFLogxK

U2 - 10.1007/s004200000193

DO - 10.1007/s004200000193

M3 - Article

VL - 74

SP - 59

EP - 62

JO - International Archives of Occupational and Environmental Health

JF - International Archives of Occupational and Environmental Health

SN - 0340-0131

IS - 1

ER -