Urinary diversion-related outcome in patients with pelvic recurrence after radical cystectomy for bladder cancer

Marcos V. Tefilli, Edward L. Gheiler, Rabi Tiguert, David Grignon, Jeffrey D. Forman, J. Edson Pontes, David P. Wood

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Objectives. To evaluate the impact of urinary diversion on disease status, complications, and subsequent treatment in patients with pelvic tumor recurrence after radical cystectomy for bladder cancer. Methods. A retrospective review of 201 consecutive cases of radical cystectomy for bladder cancer, performed at our institution between March 1991 and March 1996, identified 33 patients (16.4%)with disease recurrence in the pelvis with or without systemic metastasis. Urinary diversion in patients with tumor recurrence was an ileal conduit, continent cutaneous diversion, or orthotopic neobladder in 19, 3, and 11 patients, respectively. The mean follow-up for all patients undergoing cystectomy was 25.9 months (range 8 to 75). The mean time to diagnosis of local disease recurrence after cystectomy was 13.9 months (range 5 to 50). Results. In 21 (63.6%) of 33 patients, pelvic recurrence and systemic metastasis were present simultaneously. Disease recurrence was associated with poor outcome: only 8 patients (24.2%) were alive and disease free, 7 of whom had isolated local recurrence without evidence of systemic metastasis. There was no difference in overall survival or type of therapy delivered once disease recurrence was diagnosed between patients with an orthotopic neobladder and those with a cutaneous (continent or incontinent) urinary diversion. The only diversion-related complication resulting from pelvic recurrence was 1 case of tumor invasion into an orthotopic neobladder, requiring conversion to an ileal conduit. Conclusions. The type of urinary diversion did not impact a patient's risk of complications, the ability to receive salvage treatment, or overall survival once pelvic recurrence was diagnosed. Patients at high risk of pelvic recurrence should not be excluded from receiving an orthotopic urinary diversion.

Original languageEnglish (US)
Pages (from-to)999-1004
Number of pages6
JournalUrology
Volume53
Issue number5
DOIs
StatePublished - May 1999
Externally publishedYes

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Urinary Diversion
Cystectomy
Urinary Bladder Neoplasms
Recurrence
Neoplasm Metastasis
Salvage Therapy
Neoplasms
Skin
Survival
Pelvis

ASJC Scopus subject areas

  • Urology

Cite this

Tefilli, M. V., Gheiler, E. L., Tiguert, R., Grignon, D., Forman, J. D., Pontes, J. E., & Wood, D. P. (1999). Urinary diversion-related outcome in patients with pelvic recurrence after radical cystectomy for bladder cancer. Urology, 53(5), 999-1004. https://doi.org/10.1016/S0090-4295(98)00623-2

Urinary diversion-related outcome in patients with pelvic recurrence after radical cystectomy for bladder cancer. / Tefilli, Marcos V.; Gheiler, Edward L.; Tiguert, Rabi; Grignon, David; Forman, Jeffrey D.; Pontes, J. Edson; Wood, David P.

In: Urology, Vol. 53, No. 5, 05.1999, p. 999-1004.

Research output: Contribution to journalArticle

Tefilli, Marcos V. ; Gheiler, Edward L. ; Tiguert, Rabi ; Grignon, David ; Forman, Jeffrey D. ; Pontes, J. Edson ; Wood, David P. / Urinary diversion-related outcome in patients with pelvic recurrence after radical cystectomy for bladder cancer. In: Urology. 1999 ; Vol. 53, No. 5. pp. 999-1004.
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abstract = "Objectives. To evaluate the impact of urinary diversion on disease status, complications, and subsequent treatment in patients with pelvic tumor recurrence after radical cystectomy for bladder cancer. Methods. A retrospective review of 201 consecutive cases of radical cystectomy for bladder cancer, performed at our institution between March 1991 and March 1996, identified 33 patients (16.4{\%})with disease recurrence in the pelvis with or without systemic metastasis. Urinary diversion in patients with tumor recurrence was an ileal conduit, continent cutaneous diversion, or orthotopic neobladder in 19, 3, and 11 patients, respectively. The mean follow-up for all patients undergoing cystectomy was 25.9 months (range 8 to 75). The mean time to diagnosis of local disease recurrence after cystectomy was 13.9 months (range 5 to 50). Results. In 21 (63.6{\%}) of 33 patients, pelvic recurrence and systemic metastasis were present simultaneously. Disease recurrence was associated with poor outcome: only 8 patients (24.2{\%}) were alive and disease free, 7 of whom had isolated local recurrence without evidence of systemic metastasis. There was no difference in overall survival or type of therapy delivered once disease recurrence was diagnosed between patients with an orthotopic neobladder and those with a cutaneous (continent or incontinent) urinary diversion. The only diversion-related complication resulting from pelvic recurrence was 1 case of tumor invasion into an orthotopic neobladder, requiring conversion to an ileal conduit. Conclusions. The type of urinary diversion did not impact a patient's risk of complications, the ability to receive salvage treatment, or overall survival once pelvic recurrence was diagnosed. Patients at high risk of pelvic recurrence should not be excluded from receiving an orthotopic urinary diversion.",
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N2 - Objectives. To evaluate the impact of urinary diversion on disease status, complications, and subsequent treatment in patients with pelvic tumor recurrence after radical cystectomy for bladder cancer. Methods. A retrospective review of 201 consecutive cases of radical cystectomy for bladder cancer, performed at our institution between March 1991 and March 1996, identified 33 patients (16.4%)with disease recurrence in the pelvis with or without systemic metastasis. Urinary diversion in patients with tumor recurrence was an ileal conduit, continent cutaneous diversion, or orthotopic neobladder in 19, 3, and 11 patients, respectively. The mean follow-up for all patients undergoing cystectomy was 25.9 months (range 8 to 75). The mean time to diagnosis of local disease recurrence after cystectomy was 13.9 months (range 5 to 50). Results. In 21 (63.6%) of 33 patients, pelvic recurrence and systemic metastasis were present simultaneously. Disease recurrence was associated with poor outcome: only 8 patients (24.2%) were alive and disease free, 7 of whom had isolated local recurrence without evidence of systemic metastasis. There was no difference in overall survival or type of therapy delivered once disease recurrence was diagnosed between patients with an orthotopic neobladder and those with a cutaneous (continent or incontinent) urinary diversion. The only diversion-related complication resulting from pelvic recurrence was 1 case of tumor invasion into an orthotopic neobladder, requiring conversion to an ileal conduit. Conclusions. The type of urinary diversion did not impact a patient's risk of complications, the ability to receive salvage treatment, or overall survival once pelvic recurrence was diagnosed. Patients at high risk of pelvic recurrence should not be excluded from receiving an orthotopic urinary diversion.

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