Urinary excretion of radiolabelled norepinephrine after release from renal sympathetic nerves

L. R. Willis, R. W. Lappe, D. P. Henry, A. P. Evan, A. R. Terzian

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The role of tubular secretion in the excretion of tritiated norepinephrine (3H-NE) released from renal symphathetic nerves was examined. The endogenous pool of NE in renal nerves in the superficial cortex of rabbits was labelled with 3H-NE by surface application of the isotope. Release of the 3H-NE was stimulated by surface application of tyramine (T). T significantly increased the urinary excretion of nonmetabolized 3H-NE. The increase was totally prevented by cyanine 863, but was not significantly affected by probenecid. Electrical stimulation of the renal nerves after intraarterial infusion of 3H-NE produced a 9 ± 3% increase (p< 0.025) in the excretion of nonmetabolized 3H-NE, but did not affect the excretion of 3H-metabolites. The data suggest that 3H-NE released from renal neurons can be excreted largely as nonmetabolized 3H-NE by cation-specific tubular secretion.

Original languageEnglish (US)
Pages (from-to)2541-2546
Number of pages6
JournalLife Sciences
Volume27
Issue number25-26
DOIs
StatePublished - Dec 1980

Fingerprint

Norepinephrine
Kidney
Probenecid
Tyramine
Metabolites
Isotopes
Neurons
Cations
Intra Arterial Infusions
Electric Stimulation
Rabbits
cyanine 863

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Urinary excretion of radiolabelled norepinephrine after release from renal sympathetic nerves. / Willis, L. R.; Lappe, R. W.; Henry, D. P.; Evan, A. P.; Terzian, A. R.

In: Life Sciences, Vol. 27, No. 25-26, 12.1980, p. 2541-2546.

Research output: Contribution to journalArticle

Willis, L. R. ; Lappe, R. W. ; Henry, D. P. ; Evan, A. P. ; Terzian, A. R. / Urinary excretion of radiolabelled norepinephrine after release from renal sympathetic nerves. In: Life Sciences. 1980 ; Vol. 27, No. 25-26. pp. 2541-2546.
@article{098d1193d4054256b02136b522e0ab1a,
title = "Urinary excretion of radiolabelled norepinephrine after release from renal sympathetic nerves",
abstract = "The role of tubular secretion in the excretion of tritiated norepinephrine (3H-NE) released from renal symphathetic nerves was examined. The endogenous pool of NE in renal nerves in the superficial cortex of rabbits was labelled with 3H-NE by surface application of the isotope. Release of the 3H-NE was stimulated by surface application of tyramine (T). T significantly increased the urinary excretion of nonmetabolized 3H-NE. The increase was totally prevented by cyanine 863, but was not significantly affected by probenecid. Electrical stimulation of the renal nerves after intraarterial infusion of 3H-NE produced a 9 ± 3{\%} increase (p< 0.025) in the excretion of nonmetabolized 3H-NE, but did not affect the excretion of 3H-metabolites. The data suggest that 3H-NE released from renal neurons can be excreted largely as nonmetabolized 3H-NE by cation-specific tubular secretion.",
author = "Willis, {L. R.} and Lappe, {R. W.} and Henry, {D. P.} and Evan, {A. P.} and Terzian, {A. R.}",
year = "1980",
month = "12",
doi = "10.1016/0024-3205(80)90536-6",
language = "English (US)",
volume = "27",
pages = "2541--2546",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "25-26",

}

TY - JOUR

T1 - Urinary excretion of radiolabelled norepinephrine after release from renal sympathetic nerves

AU - Willis, L. R.

AU - Lappe, R. W.

AU - Henry, D. P.

AU - Evan, A. P.

AU - Terzian, A. R.

PY - 1980/12

Y1 - 1980/12

N2 - The role of tubular secretion in the excretion of tritiated norepinephrine (3H-NE) released from renal symphathetic nerves was examined. The endogenous pool of NE in renal nerves in the superficial cortex of rabbits was labelled with 3H-NE by surface application of the isotope. Release of the 3H-NE was stimulated by surface application of tyramine (T). T significantly increased the urinary excretion of nonmetabolized 3H-NE. The increase was totally prevented by cyanine 863, but was not significantly affected by probenecid. Electrical stimulation of the renal nerves after intraarterial infusion of 3H-NE produced a 9 ± 3% increase (p< 0.025) in the excretion of nonmetabolized 3H-NE, but did not affect the excretion of 3H-metabolites. The data suggest that 3H-NE released from renal neurons can be excreted largely as nonmetabolized 3H-NE by cation-specific tubular secretion.

AB - The role of tubular secretion in the excretion of tritiated norepinephrine (3H-NE) released from renal symphathetic nerves was examined. The endogenous pool of NE in renal nerves in the superficial cortex of rabbits was labelled with 3H-NE by surface application of the isotope. Release of the 3H-NE was stimulated by surface application of tyramine (T). T significantly increased the urinary excretion of nonmetabolized 3H-NE. The increase was totally prevented by cyanine 863, but was not significantly affected by probenecid. Electrical stimulation of the renal nerves after intraarterial infusion of 3H-NE produced a 9 ± 3% increase (p< 0.025) in the excretion of nonmetabolized 3H-NE, but did not affect the excretion of 3H-metabolites. The data suggest that 3H-NE released from renal neurons can be excreted largely as nonmetabolized 3H-NE by cation-specific tubular secretion.

UR - http://www.scopus.com/inward/record.url?scp=0019257111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019257111&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(80)90536-6

DO - 10.1016/0024-3205(80)90536-6

M3 - Article

C2 - 7012510

AN - SCOPUS:0019257111

VL - 27

SP - 2541

EP - 2546

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 25-26

ER -