Urinary excretion of radiolabelled norepinephrine after release from renal sympathetic nerves

L. R. Willis, R. W. Lappe, D. P. Henry, A. P. Evan, A. R. Terzian

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The role of tubular secretion in the excretion of tritiated norepinephrine (3H-NE) released from renal symphathetic nerves was examined. The endogenous pool of NE in renal nerves in the superficial cortex of rabbits was labelled with 3H-NE by surface application of the isotope. Release of the 3H-NE was stimulated by surface application of tyramine (T). T significantly increased the urinary excretion of nonmetabolized 3H-NE. The increase was totally prevented by cyanine 863, but was not significantly affected by probenecid. Electrical stimulation of the renal nerves after intraarterial infusion of 3H-NE produced a 9 ± 3% increase (p< 0.025) in the excretion of nonmetabolized 3H-NE, but did not affect the excretion of 3H-metabolites. The data suggest that 3H-NE released from renal neurons can be excreted largely as nonmetabolized 3H-NE by cation-specific tubular secretion.

Original languageEnglish (US)
Pages (from-to)2541-2546
Number of pages6
JournalLife Sciences
Volume27
Issue number25-26
DOIs
StatePublished - Dec 1980

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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