Urine GABA levels in ovarian cancer patients: Elevated GABA in malignancy

Catherine S. Nicholson-Guthrie, George D. Guthrie, Gregory P. Sutton, John Baenziger

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The association of malignancy with elevated diamine oxidase (DAO), an enzyme producing gamma-aminobutyric acid (GABA) is well documented. In ovarian cancer, increased DAO occurs in the malignant tissues and plasma. Since higher DAO levels cause GABA accumulation, elevated GABA may occur in ovarian cancer and be reflected in urine. We tested this hypothesis and found that half the ovarian cancer patients had a clearly elevated urine GABA, a result that is in agreement with previous reports on DAO and malignancy. The published findings on DAO, GABA and malignancy suggest that elevated GABA is associated with cancer. This proposal could lead to a GABA urine monitor or new directions in cancer treatment or research. (C) 2001 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)27-30
Number of pages4
JournalCancer Letters
Volume162
Issue number1
DOIs
StatePublished - Jan 10 2001

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Amine Oxidase (Copper-Containing)
Ovarian Neoplasms
gamma-Aminobutyric Acid
Urine
Neoplasms
Enzymes
Research

Keywords

  • Diamine oxidase
  • Gamma-aminobutyric acid
  • Malignancy
  • Ovarian cancer
  • Urine GABA

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Urine GABA levels in ovarian cancer patients : Elevated GABA in malignancy. / Nicholson-Guthrie, Catherine S.; Guthrie, George D.; Sutton, Gregory P.; Baenziger, John.

In: Cancer Letters, Vol. 162, No. 1, 10.01.2001, p. 27-30.

Research output: Contribution to journalArticle

Nicholson-Guthrie, Catherine S. ; Guthrie, George D. ; Sutton, Gregory P. ; Baenziger, John. / Urine GABA levels in ovarian cancer patients : Elevated GABA in malignancy. In: Cancer Letters. 2001 ; Vol. 162, No. 1. pp. 27-30.
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