Urothelial carcinoma following augmentation cystoplasty: An aggressive variant with distinct clinicopathological characteristics and molecular genetic alterations

Ming Tse Sung, Shaobo Zhang, Antonio Lopez-Beltran, Rodolfo Montironi, Mingsheng Wang, Darrell Davidson, Michael Koch, Mark P. Cain, Richard C. Rink, Liang Cheng

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Aims: Patients who have undergone intestinal augmentation cystoplasty are at risk for developing latent vesicle malignancy. The aim was to evaluate the histological and immunohistochemical characteristics and molecular genetic alterations in these neoplasms. Methods and results: Four patients developing urothelial neoplasms after augmentation cystoplasty were included in the current study. The mean age of the patients, including two men and two women, was 37 years. The latency from bladder augmentation to developing malignancy ranged from 17 to 21 years (mean 19 years). All patients died of cancer shortly after diagnosis (mean 5 months). In the morphological evaluation, all tumours were high-grade (grade 3) invasive urothelial carcinoma comprising various architectural patterns with brisk mitoses and tumour necrosis. Three harboured glandular differentiation and the remaining one showed squamous differentiation. All cases revealed abnormal decreasing b-catenin expression. Two tumours showed nuclear expression of CDX2. On UroVysion fluorescence in situ hybridization (FISH) analysis, all tumours displayed characteristic chromosomal abnormalities. Point mutations of both FGFR3 and p53 genes were identified in one case. Conclusions: Urothelial carcinomas developed after augmentation cystoplasty are extremely aggressive and exhibit distinct morphological, immunohistochemical and genetic characteristics. UroVysion FISH analysis may offer a surveillance strategy in patients who undergo augmentation cystoplasty.

Original languageEnglish
Pages (from-to)161-173
Number of pages13
JournalHistopathology
Volume55
Issue number2
DOIs
StatePublished - Aug 2009

Fingerprint

Molecular Biology
Carcinoma
Neoplasms
Fluorescence In Situ Hybridization
Catenins
p53 Genes
Point Mutation
Mitosis
Chromosome Aberrations
Urinary Bladder
Necrosis

Keywords

  • Augmentation cystoplasty
  • Fibroblast growth factor receptor 3
  • Fluorescence in situ hybridization
  • Neoplasia
  • P53 mutation
  • Urinary bladder

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Urothelial carcinoma following augmentation cystoplasty : An aggressive variant with distinct clinicopathological characteristics and molecular genetic alterations. / Sung, Ming Tse; Zhang, Shaobo; Lopez-Beltran, Antonio; Montironi, Rodolfo; Wang, Mingsheng; Davidson, Darrell; Koch, Michael; Cain, Mark P.; Rink, Richard C.; Cheng, Liang.

In: Histopathology, Vol. 55, No. 2, 08.2009, p. 161-173.

Research output: Contribution to journalArticle

Sung, Ming Tse ; Zhang, Shaobo ; Lopez-Beltran, Antonio ; Montironi, Rodolfo ; Wang, Mingsheng ; Davidson, Darrell ; Koch, Michael ; Cain, Mark P. ; Rink, Richard C. ; Cheng, Liang. / Urothelial carcinoma following augmentation cystoplasty : An aggressive variant with distinct clinicopathological characteristics and molecular genetic alterations. In: Histopathology. 2009 ; Vol. 55, No. 2. pp. 161-173.
@article{93b89cb0291b4399a477d3d5d5d69e5b,
title = "Urothelial carcinoma following augmentation cystoplasty: An aggressive variant with distinct clinicopathological characteristics and molecular genetic alterations",
abstract = "Aims: Patients who have undergone intestinal augmentation cystoplasty are at risk for developing latent vesicle malignancy. The aim was to evaluate the histological and immunohistochemical characteristics and molecular genetic alterations in these neoplasms. Methods and results: Four patients developing urothelial neoplasms after augmentation cystoplasty were included in the current study. The mean age of the patients, including two men and two women, was 37 years. The latency from bladder augmentation to developing malignancy ranged from 17 to 21 years (mean 19 years). All patients died of cancer shortly after diagnosis (mean 5 months). In the morphological evaluation, all tumours were high-grade (grade 3) invasive urothelial carcinoma comprising various architectural patterns with brisk mitoses and tumour necrosis. Three harboured glandular differentiation and the remaining one showed squamous differentiation. All cases revealed abnormal decreasing b-catenin expression. Two tumours showed nuclear expression of CDX2. On UroVysion fluorescence in situ hybridization (FISH) analysis, all tumours displayed characteristic chromosomal abnormalities. Point mutations of both FGFR3 and p53 genes were identified in one case. Conclusions: Urothelial carcinomas developed after augmentation cystoplasty are extremely aggressive and exhibit distinct morphological, immunohistochemical and genetic characteristics. UroVysion FISH analysis may offer a surveillance strategy in patients who undergo augmentation cystoplasty.",
keywords = "Augmentation cystoplasty, Fibroblast growth factor receptor 3, Fluorescence in situ hybridization, Neoplasia, P53 mutation, Urinary bladder",
author = "Sung, {Ming Tse} and Shaobo Zhang and Antonio Lopez-Beltran and Rodolfo Montironi and Mingsheng Wang and Darrell Davidson and Michael Koch and Cain, {Mark P.} and Rink, {Richard C.} and Liang Cheng",
year = "2009",
month = "8",
doi = "10.1111/j.1365-2559.2009.03363.x",
language = "English",
volume = "55",
pages = "161--173",
journal = "Histopathology",
issn = "0309-0167",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Urothelial carcinoma following augmentation cystoplasty

T2 - An aggressive variant with distinct clinicopathological characteristics and molecular genetic alterations

AU - Sung, Ming Tse

AU - Zhang, Shaobo

AU - Lopez-Beltran, Antonio

AU - Montironi, Rodolfo

AU - Wang, Mingsheng

AU - Davidson, Darrell

AU - Koch, Michael

AU - Cain, Mark P.

AU - Rink, Richard C.

AU - Cheng, Liang

PY - 2009/8

Y1 - 2009/8

N2 - Aims: Patients who have undergone intestinal augmentation cystoplasty are at risk for developing latent vesicle malignancy. The aim was to evaluate the histological and immunohistochemical characteristics and molecular genetic alterations in these neoplasms. Methods and results: Four patients developing urothelial neoplasms after augmentation cystoplasty were included in the current study. The mean age of the patients, including two men and two women, was 37 years. The latency from bladder augmentation to developing malignancy ranged from 17 to 21 years (mean 19 years). All patients died of cancer shortly after diagnosis (mean 5 months). In the morphological evaluation, all tumours were high-grade (grade 3) invasive urothelial carcinoma comprising various architectural patterns with brisk mitoses and tumour necrosis. Three harboured glandular differentiation and the remaining one showed squamous differentiation. All cases revealed abnormal decreasing b-catenin expression. Two tumours showed nuclear expression of CDX2. On UroVysion fluorescence in situ hybridization (FISH) analysis, all tumours displayed characteristic chromosomal abnormalities. Point mutations of both FGFR3 and p53 genes were identified in one case. Conclusions: Urothelial carcinomas developed after augmentation cystoplasty are extremely aggressive and exhibit distinct morphological, immunohistochemical and genetic characteristics. UroVysion FISH analysis may offer a surveillance strategy in patients who undergo augmentation cystoplasty.

AB - Aims: Patients who have undergone intestinal augmentation cystoplasty are at risk for developing latent vesicle malignancy. The aim was to evaluate the histological and immunohistochemical characteristics and molecular genetic alterations in these neoplasms. Methods and results: Four patients developing urothelial neoplasms after augmentation cystoplasty were included in the current study. The mean age of the patients, including two men and two women, was 37 years. The latency from bladder augmentation to developing malignancy ranged from 17 to 21 years (mean 19 years). All patients died of cancer shortly after diagnosis (mean 5 months). In the morphological evaluation, all tumours were high-grade (grade 3) invasive urothelial carcinoma comprising various architectural patterns with brisk mitoses and tumour necrosis. Three harboured glandular differentiation and the remaining one showed squamous differentiation. All cases revealed abnormal decreasing b-catenin expression. Two tumours showed nuclear expression of CDX2. On UroVysion fluorescence in situ hybridization (FISH) analysis, all tumours displayed characteristic chromosomal abnormalities. Point mutations of both FGFR3 and p53 genes were identified in one case. Conclusions: Urothelial carcinomas developed after augmentation cystoplasty are extremely aggressive and exhibit distinct morphological, immunohistochemical and genetic characteristics. UroVysion FISH analysis may offer a surveillance strategy in patients who undergo augmentation cystoplasty.

KW - Augmentation cystoplasty

KW - Fibroblast growth factor receptor 3

KW - Fluorescence in situ hybridization

KW - Neoplasia

KW - P53 mutation

KW - Urinary bladder

UR - http://www.scopus.com/inward/record.url?scp=68749107464&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68749107464&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2559.2009.03363.x

DO - 10.1111/j.1365-2559.2009.03363.x

M3 - Article

C2 - 19694823

AN - SCOPUS:68749107464

VL - 55

SP - 161

EP - 173

JO - Histopathology

JF - Histopathology

SN - 0309-0167

IS - 2

ER -