Urothelial dysplasia and other flat lesions of the urinary bladder: clinicopathologic and molecular features

Kurt B. Hodges, Antonio Lopez-Beltran, Darrell D. Davidson, Rodolfo Montironi, Liang Cheng

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

The 2004 World Health Organization classification system for urothelial neoplasia classifies flat-related preneoplastic lesions as urothelial hyperplasia (flat and papillary), reactive urothelial atypia, urothelial atypia of unknown significance, urothelial dysplasia (low-grade intraurothelial neoplasia), and urothelial carcinoma in situ (high-grade intraurothelial neoplasia). Each lesion is defined with precise nomenclature and strict morphologic criteria. In many cases, morphologic features alone suffice for diagnosis. Other cases may require a panel of immunohistochemical antibodies consisting of cytokeratin 20, p53, and CD44 for diagnosis. Recent molecular studies have provided further insight into the premalignant potential of these urothelial lesions. Herein, we present a review of flat urothelial lesions of the urinary bladder as defined by the 2004 World Health Organization classification with focus on the clinicopathologic, immunohistochemical, and molecular features.

Original languageEnglish (US)
Pages (from-to)155-162
Number of pages8
JournalHuman pathology
Volume41
Issue number2
DOIs
StatePublished - Feb 1 2010

Keywords

  • Atypia of unknown significance
  • Bladder
  • Flat lesions
  • Molecular pathogenesis
  • Papillary hyperplasia
  • Urothelial dysplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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