Urothelial dysplasia and other flat lesions of the urinary bladder

clinicopathologic and molecular features

Kurt B. Hodges, Antonio Lopez-Beltran, Darrell Davidson, Rodolfo Montironi, Liang Cheng

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The 2004 World Health Organization classification system for urothelial neoplasia classifies flat-related preneoplastic lesions as urothelial hyperplasia (flat and papillary), reactive urothelial atypia, urothelial atypia of unknown significance, urothelial dysplasia (low-grade intraurothelial neoplasia), and urothelial carcinoma in situ (high-grade intraurothelial neoplasia). Each lesion is defined with precise nomenclature and strict morphologic criteria. In many cases, morphologic features alone suffice for diagnosis. Other cases may require a panel of immunohistochemical antibodies consisting of cytokeratin 20, p53, and CD44 for diagnosis. Recent molecular studies have provided further insight into the premalignant potential of these urothelial lesions. Herein, we present a review of flat urothelial lesions of the urinary bladder as defined by the 2004 World Health Organization classification with focus on the clinicopathologic, immunohistochemical, and molecular features.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalHuman Pathology
Volume41
Issue number2
DOIs
StatePublished - Feb 2010

Fingerprint

Urinary Bladder
Keratin-20
Neoplasms
Carcinoma in Situ
Terminology
Hyperplasia
Antibodies

Keywords

  • Atypia of unknown significance
  • Bladder
  • Flat lesions
  • Molecular pathogenesis
  • Papillary hyperplasia
  • Urothelial dysplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Urothelial dysplasia and other flat lesions of the urinary bladder : clinicopathologic and molecular features. / Hodges, Kurt B.; Lopez-Beltran, Antonio; Davidson, Darrell; Montironi, Rodolfo; Cheng, Liang.

In: Human Pathology, Vol. 41, No. 2, 02.2010, p. 155-162.

Research output: Contribution to journalArticle

Hodges, Kurt B. ; Lopez-Beltran, Antonio ; Davidson, Darrell ; Montironi, Rodolfo ; Cheng, Liang. / Urothelial dysplasia and other flat lesions of the urinary bladder : clinicopathologic and molecular features. In: Human Pathology. 2010 ; Vol. 41, No. 2. pp. 155-162.
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