Urticaria and angioedema in renal cell cancer patients treated with IL-2

Theodore F. Logan, Giovanni Strippoli, Macy I. Levine

Research output: Contribution to journalArticle


Interleukin-2 therapy has produced significant improvement in a proportion of patients with renal cell cancer. Dermatologic side effects, such as erythema, have been very common. However, we could find only 2 reports of urticaria in the medical literature. Here, we report 8 patients with renal cell cancer who developed urticaria in association with interleukin-2 therapy. The hives tended to occur at the end of a treatment cycle. Skin tests with IL-2 were negative in two patients. Urticaria did not worsen or consistently occur with repeated courses of interleukin-2 and anaphylaxis was not observed in any patient. Six of the 8 patients previously had urticaria unrelated to IL-2 therapy.

Original languageEnglish (US)
Pages (from-to)584-588
Number of pages5
JournalCancer Investigation
Issue number7
StatePublished - Oct 1 2007


  • Angioedema
  • Interleukin-2 (IL-2)
  • Renal cell carcinoma
  • Urticaria

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Urticaria and angioedema in renal cell cancer patients treated with IL-2'. Together they form a unique fingerprint.

  • Cite this