Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders

Benjamin L. Handen, Cynthia R. Johnson, Eric M. Butter, Luc Lecavalier, Lawrence Scahill, Michael G. Aman, Christopher J. McDougle, L. Eugene Arnold, Naomi B. Swiezy, Denis G. Sukhodolsky, James A. Mulick, Susan W. White, Karen Bearss, Jill A. Hollway, Kimberly A. Stigler, James Dziura, Sunkyung Yu, Kelley Sacco, Benedetto Vitiello

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A Structured Observational Analog Procedure (SOAP), an analogue measure of parent-child interactions, was used to assess treatment outcome in children with Autism Spectrum Disorder and serious behavior problems. It served as a secondary outcome measure in a 24-week, randomized trial of risperidone (MED; N = 49) versus risperidone plus parent training (COMB; n = 75) (ages 4-13 years). At 24-weeks, there was 28 % reduction in child inappropriate behavior during a Demand Condition (p =.0002) and 12 % increase in compliance to parental requests (p =.004) for the two treatment conditions combined. Parents displayed 64 % greater use of positive reinforcement (p =.001) and fewer repeated requests for compliance (p < .0001). In the analysis of covariance (ANCOVA), COMB parents used significantly more positive reinforcement (p =.01) and fewer restrictive statements (p < .05) than MED parents. The SOAP is sensitive to change in child and parent behavior as a function of risperidone alone and in combination with PMT and can serve as a valuable complement to parent and clinician-based measures.

Original languageEnglish (US)
Pages (from-to)355-371
Number of pages17
JournalJournal of Developmental and Physical Disabilities
Volume25
Issue number3
DOIs
StatePublished - Jun 1 2013

Keywords

  • Autism
  • Autism spectrum disorder
  • Behavioral interventions
  • Clinical trials
  • Observational measures
  • Parent training

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Physical Therapy, Sports Therapy and Rehabilitation

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    Handen, B. L., Johnson, C. R., Butter, E. M., Lecavalier, L., Scahill, L., Aman, M. G., McDougle, C. J., Arnold, L. E., Swiezy, N. B., Sukhodolsky, D. G., Mulick, J. A., White, S. W., Bearss, K., Hollway, J. A., Stigler, K. A., Dziura, J., Yu, S., Sacco, K., & Vitiello, B. (2013). Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders. Journal of Developmental and Physical Disabilities, 25(3), 355-371. https://doi.org/10.1007/s10882-012-9316-y