Use of a Natural Porcine Extracellular Matrix With Negative Pressure Wound Therapy Hastens the Healing Rate in Stage 4 Pressure Ulcers

Walid Mari, Sara Younes, Jaree Naqvi, Abdelfattah Abu Issa, Terry L. Oroszi, David R. Cool, Jeffrey Travers, Richard Simman

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Chronic wounds are physically debilitating and painful and are responsible for the addition of more than $25 billion annually in health care costs in the United States. Extracellular matrix (ECM) replacements have been demonstrated to aid in wound healing by providing an optimal environment to facilitate the healing process. OBJECTIVE: This study examines the healing rates of stage 4 pressure ulcers using combination of a commercially available porcine-based wound matrix dressing alongside negative pressure wound therapy (NPWT) versus using NPWT alone. MATERIALS AND METHODS: Patients were randomized to receive either the matrix plus NPWT (study) or NPWT alone (control) for stage 4 sacral pressure ulcer treatment. Wounds were photographed and measured weekly. The experimental group had their ECM dressings changed every other week and their NPWT changed twice weekly. RESULTS: A total of 16 patients, 8 study and 8 control, completed this study. After the 12-week study period, the average control patient healing rate was 45.79% as compared with the 89.98% healing rate in the study group. The difference in healing rate between control and study patients was optimal by 12 weeks. CONCLUSIONS: These studies suggest that ECM dressings may be a promising adjunctive treatment option for stage 4 pressure ulcers.

Original languageEnglish (US)
Pages (from-to)117-122
Number of pages6
JournalWounds : a compendium of clinical research and practice
Volume31
Issue number5
StatePublished - May 1 2019
Externally publishedYes

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Negative-Pressure Wound Therapy
Pressure Ulcer
Extracellular Matrix
Swine
Bandages
Wounds and Injuries
Health Care Costs
Wound Healing
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical

Cite this

Use of a Natural Porcine Extracellular Matrix With Negative Pressure Wound Therapy Hastens the Healing Rate in Stage 4 Pressure Ulcers. / Mari, Walid; Younes, Sara; Naqvi, Jaree; Issa, Abdelfattah Abu; Oroszi, Terry L.; Cool, David R.; Travers, Jeffrey; Simman, Richard.

In: Wounds : a compendium of clinical research and practice, Vol. 31, No. 5, 01.05.2019, p. 117-122.

Research output: Contribution to journalArticle

Mari, Walid ; Younes, Sara ; Naqvi, Jaree ; Issa, Abdelfattah Abu ; Oroszi, Terry L. ; Cool, David R. ; Travers, Jeffrey ; Simman, Richard. / Use of a Natural Porcine Extracellular Matrix With Negative Pressure Wound Therapy Hastens the Healing Rate in Stage 4 Pressure Ulcers. In: Wounds : a compendium of clinical research and practice. 2019 ; Vol. 31, No. 5. pp. 117-122.
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