Use of abdominal radical trachelectomy to treat cervical cancer greater than 2 cm in diameter

Balazs Lintner, Srdjan Saso, Laszlo Tarnai, Zoltan Novak, Laszlo Palfalvi, Giuseppe Del Priore, J. Richard Smith, Laszlo Ungar

Research output: Contribution to journalArticle

36 Scopus citations


Objective: Invasive cervical cancer is one of the most common cancers, with 500,000 new cases diagnosed annually. Fertility preservation has become an important component of the overall quality of life of many cancer survivors. Expert opinion has suggested that fertility-sparing surgery should be limited to those patients diagnosed with cervical cancer less than 2 cm in diameter. Our objective was to report our abdominal radical trachelectomy (ART) experience in the opposite group of patientsVthose with a cervical cancer more than 2 cm in diameter. Methods: Between 1999 and 2006, a total of 45 patients with cervical carcinoma at International Federation of Gynecology and Obstetrics stage IB1-IB2 measuring more than 2 cm in diameter underwent fertility-sparing ART and pelvic lymphadenectomy at the 3 institutions where the authors are based (Budapest, Hungary; London, United Kingdom; New York, United States). They were followed up for more than 5 years. Results: For 69% of patients (n = 31), completed ART was considered to have been curative, and no adjuvant treatment was advised. Of those patients, 93.5% (n = 29) were alive at the time of follow-up. Thirty-one percent of patients (n = 14) underwent immediate completion of radical hysterectomy. Three of 8 patients who wished to fall pregnant delivered healthy neonates. Conclusions: The 5-year survival rate (93.5%) for this case series is equal (or better) to rates reported in the literature for patient treated with radical hysterectomy. Our survival data seem to support the hypothesis that ART is a safe treatment option for patients with invasive cervical cancer lesions of more than 2 cm.

Original languageEnglish (US)
Pages (from-to)1065-1070
Number of pages6
JournalInternational Journal of Gynecological Cancer
Issue number6
StatePublished - Jul 1 2013


  • 2-cm diameter ORIGINAL STUDY
  • Abdominal radical trachelectomy
  • Early-stage cervical cancer
  • Radical hysterectomy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

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    Lintner, B., Saso, S., Tarnai, L., Novak, Z., Palfalvi, L., Del Priore, G., Smith, J. R., & Ungar, L. (2013). Use of abdominal radical trachelectomy to treat cervical cancer greater than 2 cm in diameter. International Journal of Gynecological Cancer, 23(6), 1065-1070.