Use of carbon-11 acetate and dynamic positron emission tomography to assess regional myocardial oxygen consumption in patients with acute myocardial infarction receiving thrombolysis or coronary angioplasty

Victor Kalff, Rodney J. Hicks, Gary Hutchins, Eric Topol, Markus Schwaiger

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Carbon-11 (C-11) acetate has been introduced for the noninvasive measurements of myocardial oxygen consumption. This study was designed to assess regional C-11 acetate clearance in patients with acute myocardial infarction. Thirty-one patients were studied within 8 days of acute myocardial infarction. C-11 acetate washout-rate constants were significantly lower in the infarct territory than in the remote myocardium (p < 0.008). The scintigraphic measurements correlated with heart rate-blood pressure product in the remote as well as infarct areas (0.52 and 0.48, respectively). There was no significant correlation to left ventricular ejection fraction. C-11 washout rates were significantly affected by βreceptor therapy as assessed by multiple regression analysis. Thus, C-11 acetate kinetics allow noninvasive characterization of regional myocardial oxygen demand, which may be useful in assessing the extent of myocardial injury and myocardial oxygen demand of remote myocardium.

Original languageEnglish (US)
Pages (from-to)529-535
Number of pages7
JournalThe American journal of cardiology
Volume71
Issue number7
DOIs
StatePublished - Mar 1 1993

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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