Use of Excessive Lidocaine Concentrations for Local Anesthesia

G. Bashein, Douglas P. Zipes, Stanley Nattel, Robert L. Rinkenberger

Research output: Contribution to journalLetterpeer-review

4 Scopus citations


To the Editor: I would like to point out an important and commonly held misconception: that lidocaine has to be used in a solution of at least 1 per cent concentration to produce anesthesia by means of local infiltration. This misconception is illustrated in the recent paper of Nattel et al.,1 which describes use of a 1 per cent solution for local anesthesia in 17 patients undergoing electrophysiologic studies for analysis of their cardiac arrhythmias. It was found that six of these patients had undesirable therapeutic blood concentrations of lidocaine during the studies. The regression line in their Figure 1.

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Issue number2
StatePublished - Jan 10 1980

ASJC Scopus subject areas

  • Medicine(all)

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