Use of forward genetics to discover novel regulators of NF-kappaB.

Tao Lu, George R. Stark

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Forward and reverse genetic experiments have both played important roles in revealing critical aspects of mammalian signal transduction pathways in cell culture experiments. Only recently have we begun to comprehend the depth, breadth, and complexity of these pathways and of their interrelationships. Here, we summarize successful examples in which different forward genetic approaches have led to novel discoveries in NF-kappaB signaling. We believe that forward genetics will continue to play an irreplaceable role in advancing our understanding of the complexities of the pathways that regulate the functions of this key transcription factor.

Original languageEnglish (US)
Pages (from-to)a001966
JournalCold Spring Harbor perspectives in biology
Volume2
Issue number6
DOIs
StatePublished - Jun 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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