Use of intrathecally administered morphine in the treatment of postoperative pain after lumbar spinal surgery

A prospective, double-blind, placebo-controlled study

D. A. Ross, K. Drasner, P. R. Weinstein, J. F. Flaherty, Nicholas Barbaro

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Improved control of postoperative pain is now known to reduce the incidence of morbidity. Although spinally administered narcotics have found a clear role in chest and abdominal surgery, their role in lumbar spinal surgery is debated. We conducted a prospective, double-blind, randomized, placebo-controlled trial of intrathecally administered morphine sulfate after lumbar spinal surgery in 56 patients. Patients received 0, 0.125, 0.25, or 0.5 mg of intrathecally administered morphine during extradural lumbar spinal operations, and the effects on postoperative analog pain scores, narcotic consumption, complications, and length of hospitalization were assessed. As compared with systemic narcotic administration, intrathecally administered morphine provided superior analgesia in a dose-dependent fashion without an increase in narcotic side effects. Consumption of parenteral narcotics on the first postoperative day and over the total hospitalization period decreased in correlation with increasing doses of intrathecally administered morphine. Mean length of hospitalization was significantly decreased, as compared with the control group, in patients receiving 0.25 or 0.5 mg of intrathecally administered morphine. When proper precautions are observed, intrathecally administered morphine can improve the postoperative care of patients undergoing lumbar spinal surgery.

Original languageEnglish (US)
Pages (from-to)700-704
Number of pages5
JournalNeurosurgery
Volume28
Issue number5
StatePublished - 1991
Externally publishedYes

Fingerprint

Postoperative Pain
Narcotics
Morphine
Placebos
Hospitalization
Therapeutics
Postoperative Care
Analgesia
Thorax
Randomized Controlled Trials
Morbidity
Control Groups
Incidence

Keywords

  • Discectomy
  • Intrathecal morphine
  • Laminectomy
  • Lumbar spine
  • Postoperative pain

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Use of intrathecally administered morphine in the treatment of postoperative pain after lumbar spinal surgery : A prospective, double-blind, placebo-controlled study. / Ross, D. A.; Drasner, K.; Weinstein, P. R.; Flaherty, J. F.; Barbaro, Nicholas.

In: Neurosurgery, Vol. 28, No. 5, 1991, p. 700-704.

Research output: Contribution to journalArticle

Ross, D. A. ; Drasner, K. ; Weinstein, P. R. ; Flaherty, J. F. ; Barbaro, Nicholas. / Use of intrathecally administered morphine in the treatment of postoperative pain after lumbar spinal surgery : A prospective, double-blind, placebo-controlled study. In: Neurosurgery. 1991 ; Vol. 28, No. 5. pp. 700-704.
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