Use of intravenous immunoglobulin in human disease: A review of evidence by members of the Primary Immunodeficiency Committee of the American Academy of Allergy, Asthma and Immunology

Jordan S. Orange, Elham M. Hossny, Catherine R. Weiler, Mark Ballow, Melvin Berger, Francisco A. Bonilla, Rebecca Buckley, Javier Chinen, Yehia El-Gamal, Bruce D. Mazer, Robert P. Nelson, Dhavalkumar D. Patel, Elizabeth Secord, Ricardo U. Sorensen, Richard L. Wasserman, Charlotte Cunningham-Rundles

Research output: Contribution to journalArticle

499 Scopus citations

Abstract

Human immunoglobulin prepared for intravenous administration (IGIV) has a number of important uses in the treatment of disease. Some of these are in diseases for which acceptable treatment alternatives do not exist. In this review we have evaluated the evidence underlying a wide variety of IGIV uses and make specific recommendations on the basis of these data. Given the potential risks and inherent scarcity of IGIV, careful consideration of the indications for and administration of IGIV is warranted.

Original languageEnglish (US)
Pages (from-to)S525-S553
JournalJournal of Allergy and Clinical Immunology
Volume117
Issue number4 SUPPL.
DOIs
StatePublished - Apr 2006

Keywords

  • Adverse events
  • Autoimmunity
  • IGIV
  • Immunoglobulin
  • Immunomodulation
  • Intravenous immunoglobulin
  • Primary immunodeficiency
  • Transfusion

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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