Use of molecular testing to identify a cluster of patients with polycythemia vera in eastern Pennsylvania

Vincent Seaman, Aisha Jumaan, Emad Yanni, Brian Lewis, Jonathan Neyer, Paul Roda, Mingjiang Xu, Ronald Hoffman

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: The role of the environment in the origin of polycythemia vera has not been well documented. Recently, molecular diagnostic tools have been developed to facilitate the diagnosis of polycythemia vera. A cluster of patients with polycythemia vera was suspected in three countries in eastern Pennsylvania where there have long been a concern about environment hazards. Methods: Rigorous clinical criteria and JAK2 617V>F testing were used to confirm the diagnosis of polycythemia vera in patients in this area. Participants included cases of polycythemia vera from the 2001 to 2005 state cancer registry as well as self- and physician-referred cases. Finding: A diagnosis of polycythemia vera was confirmed in 53% of 62 participants usingWHO criteria, which includes JAK2 617V>F testing. A statistically significant cluster of cases (P <0.001) was identified where the incidence of polycythemia vera was 4.3 times that of the rest of the study area. The area of the cluster contained numerous sources of hazardous material includingwaste-coal power plants and U.S. Environmental Protection Agency Superfund sites. Interpretation: The diagnosis of polycythemia vera based solely on clinical criteria is frequently erroneous, suggesting that our prior knowledge of the epidemiology of this disease might be inaccurate. The JAK2 617V>F mutational analysis provides diagnostic clarity and permitted the confirmation of a cluster of polycythemia vera cases not identified by traditional clinical and pathologic diagnostic criteria. The close proximity of this cluster to known areas of hazardous material exposure raises concern that such environmental factors might play a role in the origin of polycythemia vera.

Original languageEnglish (US)
Pages (from-to)534-540
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume18
Issue number2
DOIs
StatePublished - Feb 2009
Externally publishedYes

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Polycythemia Vera
Hazardous Substances
Molecular Pathology
Registries
Physicians

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Use of molecular testing to identify a cluster of patients with polycythemia vera in eastern Pennsylvania. / Seaman, Vincent; Jumaan, Aisha; Yanni, Emad; Lewis, Brian; Neyer, Jonathan; Roda, Paul; Xu, Mingjiang; Hoffman, Ronald.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 18, No. 2, 02.2009, p. 534-540.

Research output: Contribution to journalArticle

Seaman, Vincent ; Jumaan, Aisha ; Yanni, Emad ; Lewis, Brian ; Neyer, Jonathan ; Roda, Paul ; Xu, Mingjiang ; Hoffman, Ronald. / Use of molecular testing to identify a cluster of patients with polycythemia vera in eastern Pennsylvania. In: Cancer Epidemiology Biomarkers and Prevention. 2009 ; Vol. 18, No. 2. pp. 534-540.
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