Use of non-mammalian alternative models for neurotoxicological study.

Randall T. Peterson, Richard Nass, Windy A. Boyd, Jonathan H. Freedman, Ke Dong, Toshio Narahashi

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

The field of neurotoxicology needs to satisfy two opposing demands: the testing of a growing list of chemicals, and resource limitations and ethical concerns associated with testing using traditional mammalian species. National and international government agencies have defined a need to reduce, refine or replace mammalian species in toxicological testing with alternative testing methods and non-mammalian models. Toxicological assays using alternative animal models may relieve some of this pressure by allowing testing of more compounds while reducing expense and using fewer mammals. Recent advances in genetic technologies and the strong conservation between human and non-mammalian genomes allow for the dissection of the molecular pathways involved in neurotoxicological responses and neurological diseases using genetically tractable organisms. In this review, applications of four non-mammalian species, zebrafish, cockroach, Drosophila, and Caenorhabditis elegans, in the investigation of neurotoxicology and neurological diseases are presented.

Original languageEnglish (US)
Pages (from-to)546-555
Number of pages10
JournalNeuroToxicology
Volume29
Issue number3
DOIs
StatePublished - May 2008

Fingerprint

Toxicology
International Agencies
Government Agencies
Cockroaches
Federal Government
Caenorhabditis elegans
Testing
Zebrafish
Drosophila
Dissection
Mammals
Animal Models
Genome
Technology
Pressure
Assays
Conservation
Animals
Genes

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

Cite this

Peterson, R. T., Nass, R., Boyd, W. A., Freedman, J. H., Dong, K., & Narahashi, T. (2008). Use of non-mammalian alternative models for neurotoxicological study. NeuroToxicology, 29(3), 546-555. https://doi.org/10.1016/j.neuro.2008.04.006

Use of non-mammalian alternative models for neurotoxicological study. / Peterson, Randall T.; Nass, Richard; Boyd, Windy A.; Freedman, Jonathan H.; Dong, Ke; Narahashi, Toshio.

In: NeuroToxicology, Vol. 29, No. 3, 05.2008, p. 546-555.

Research output: Contribution to journalArticle

Peterson, RT, Nass, R, Boyd, WA, Freedman, JH, Dong, K & Narahashi, T 2008, 'Use of non-mammalian alternative models for neurotoxicological study.', NeuroToxicology, vol. 29, no. 3, pp. 546-555. https://doi.org/10.1016/j.neuro.2008.04.006
Peterson, Randall T. ; Nass, Richard ; Boyd, Windy A. ; Freedman, Jonathan H. ; Dong, Ke ; Narahashi, Toshio. / Use of non-mammalian alternative models for neurotoxicological study. In: NeuroToxicology. 2008 ; Vol. 29, No. 3. pp. 546-555.
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