Usefulness of diffusion-weighted imaging in the evaluation of renal masses

Kumaresan Sandrasegaran, Chandru P. Sundaram, Raja Ramaswamy, Fatih M. Akisik, Magnus P. Rydberg, Chen Lin, Alex M. Aisen

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Abstract

OBJECTIVE. The objective of our study was to assess the value of diffusion-weighted imaging in differentiating among the various subgroups of renal masses. MATERIALS AND METHODS. This retrospective study measured the apparent diffusion coefficients (ADCs) of renal masses. Malignant lesions were confirmed with surgical pathology results. Benign cystic lesions were stable without treatment for a minimum followup of 24 months. RESULTS. There were 20 and 22 patients, respectively, with benign lesions (three abscess, 31 cysts) and malignant lesions (17 clear cell, five papillary, one chromophobe, and two transitional cell cancers). The malignant lesions were larger than the benign lesions (mean diameter, 4.2 vs 2.6 cm, respectively; p = 0.01, Student's t test). The ADC values of the benign lesions were significantly higher than those of the malignant lesions (mean, 2.72 vs 1.88 × 10-3 mm 2/s; p < 0.0001). The ADCs of the 31 benign cysts were significantly higher than those of the seven cystic renal cancers (2.77 vs 2.02 × 10-3 mm2/s; p < 0.001). There was no significant difference between the ADCs of clear cell cancers and non-clear cell cancers (1.85 vs 1.97 × 10-3 mm2/s; p = 0.18), but an ADC of less than 1.79 × 10-3 mm2/s was seen only with clear cell cancer. The ADCs of high-grade clear cell cancers (Fuhrman grades III and IV) tended to be lower than those of low-grade clear cell cancers (1.77 vs 1.95 × 10-3 mm2/s; p = 0.12). Among the clear cell cancers, an ADC value of greater than 2.12 × 10-3 mm2/s was seen only with low-grade histology. For differentiating benign from malignant lesions, receiver operating characteristic (ROC) analysis showed an area under the ROC curve of 0.989 (95% CI, 0.919-0.996; p < 0.0001). CONCLUSION. ADC measurements may aid in differentiating among the various subgroups of renal masses, particularly benign cystic lesions from cystic renal cell cancers.

Original languageEnglish (US)
Pages (from-to)438-445
Number of pages8
JournalAmerican Journal of Roentgenology
Volume194
Issue number2
DOIs
StatePublished - Feb 1 2010

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Kidney
Neoplasms
ROC Curve
Cysts
Surgical Pathology
Kidney Neoplasms
Renal Cell Carcinoma
Abscess
Histology
Retrospective Studies
Students

Keywords

  • Clear cell renal cell carcinoma
  • Diffusion-weighted imaging
  • MRI
  • Papillary renal cell carcinoma
  • Renal neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Usefulness of diffusion-weighted imaging in the evaluation of renal masses. / Sandrasegaran, Kumaresan; Sundaram, Chandru P.; Ramaswamy, Raja; Akisik, Fatih M.; Rydberg, Magnus P.; Lin, Chen; Aisen, Alex M.

In: American Journal of Roentgenology, Vol. 194, No. 2, 01.02.2010, p. 438-445.

Research output: Contribution to journalArticle

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AU - Ramaswamy, Raja

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AU - Rydberg, Magnus P.

AU - Lin, Chen

AU - Aisen, Alex M.

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N2 - OBJECTIVE. The objective of our study was to assess the value of diffusion-weighted imaging in differentiating among the various subgroups of renal masses. MATERIALS AND METHODS. This retrospective study measured the apparent diffusion coefficients (ADCs) of renal masses. Malignant lesions were confirmed with surgical pathology results. Benign cystic lesions were stable without treatment for a minimum followup of 24 months. RESULTS. There were 20 and 22 patients, respectively, with benign lesions (three abscess, 31 cysts) and malignant lesions (17 clear cell, five papillary, one chromophobe, and two transitional cell cancers). The malignant lesions were larger than the benign lesions (mean diameter, 4.2 vs 2.6 cm, respectively; p = 0.01, Student's t test). The ADC values of the benign lesions were significantly higher than those of the malignant lesions (mean, 2.72 vs 1.88 × 10-3 mm 2/s; p < 0.0001). The ADCs of the 31 benign cysts were significantly higher than those of the seven cystic renal cancers (2.77 vs 2.02 × 10-3 mm2/s; p < 0.001). There was no significant difference between the ADCs of clear cell cancers and non-clear cell cancers (1.85 vs 1.97 × 10-3 mm2/s; p = 0.18), but an ADC of less than 1.79 × 10-3 mm2/s was seen only with clear cell cancer. The ADCs of high-grade clear cell cancers (Fuhrman grades III and IV) tended to be lower than those of low-grade clear cell cancers (1.77 vs 1.95 × 10-3 mm2/s; p = 0.12). Among the clear cell cancers, an ADC value of greater than 2.12 × 10-3 mm2/s was seen only with low-grade histology. For differentiating benign from malignant lesions, receiver operating characteristic (ROC) analysis showed an area under the ROC curve of 0.989 (95% CI, 0.919-0.996; p < 0.0001). CONCLUSION. ADC measurements may aid in differentiating among the various subgroups of renal masses, particularly benign cystic lesions from cystic renal cell cancers.

AB - OBJECTIVE. The objective of our study was to assess the value of diffusion-weighted imaging in differentiating among the various subgroups of renal masses. MATERIALS AND METHODS. This retrospective study measured the apparent diffusion coefficients (ADCs) of renal masses. Malignant lesions were confirmed with surgical pathology results. Benign cystic lesions were stable without treatment for a minimum followup of 24 months. RESULTS. There were 20 and 22 patients, respectively, with benign lesions (three abscess, 31 cysts) and malignant lesions (17 clear cell, five papillary, one chromophobe, and two transitional cell cancers). The malignant lesions were larger than the benign lesions (mean diameter, 4.2 vs 2.6 cm, respectively; p = 0.01, Student's t test). The ADC values of the benign lesions were significantly higher than those of the malignant lesions (mean, 2.72 vs 1.88 × 10-3 mm 2/s; p < 0.0001). The ADCs of the 31 benign cysts were significantly higher than those of the seven cystic renal cancers (2.77 vs 2.02 × 10-3 mm2/s; p < 0.001). There was no significant difference between the ADCs of clear cell cancers and non-clear cell cancers (1.85 vs 1.97 × 10-3 mm2/s; p = 0.18), but an ADC of less than 1.79 × 10-3 mm2/s was seen only with clear cell cancer. The ADCs of high-grade clear cell cancers (Fuhrman grades III and IV) tended to be lower than those of low-grade clear cell cancers (1.77 vs 1.95 × 10-3 mm2/s; p = 0.12). Among the clear cell cancers, an ADC value of greater than 2.12 × 10-3 mm2/s was seen only with low-grade histology. For differentiating benign from malignant lesions, receiver operating characteristic (ROC) analysis showed an area under the ROC curve of 0.989 (95% CI, 0.919-0.996; p < 0.0001). CONCLUSION. ADC measurements may aid in differentiating among the various subgroups of renal masses, particularly benign cystic lesions from cystic renal cell cancers.

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KW - Papillary renal cell carcinoma

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