Uterine allotransplantation in the rabbit model using a macrovascular patch technique

Krishen Sieunarine, Dimitrios Doumplis, Eugene Kuzmin, David J. Corless, Nadey S. Hakim, Giuseppe Del Priore, J. Richard Smith

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

The uterus and its blood supply en bloc were successfully harvested with an aortic-caval macrovascular patch in animal and human cadaveric models. The objective of this study was to assess the technical feasibility of uterine allotransplantation in the rabbit. Six uterine allotransplants were performed. This involved harvesting the uterine allograft with an aortic-caval vascular patch en bloc in the donor. After 1 hour of cold ischemic storage, the uterine allograft was transplanted to the recipient using an aortic-aortal cavacaval end to side anastomosis. Our 6 rabbit recipients surgically survived the procedure. After postmortem and histological analyses in the short term, all of the uteri appeared viable with no evidence of graft vessel thromboses. Postoperative complications included limb paraplegia, pulmonary emboli, and intraperitoneal hemorrhage. The feasibility of uterine allotransplantation using a macrovascular patch, in anatomical and surgical terms, has been proven. Further research will lead to a successful program of fertility restoration.

Original languageEnglish (US)
Pages (from-to)288-294
Number of pages7
JournalInternational Surgery
Volume93
Issue number5
StatePublished - Sep 1 2008

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Keywords

  • Infertility
  • Macrovascular patch
  • Uterine allotransplantation

ASJC Scopus subject areas

  • Surgery

Cite this

Sieunarine, K., Doumplis, D., Kuzmin, E., Corless, D. J., Hakim, N. S., Del Priore, G., & Richard Smith, J. (2008). Uterine allotransplantation in the rabbit model using a macrovascular patch technique. International Surgery, 93(5), 288-294.