Uterus transplant: Evidence and ethics

Anjana Nair, Jeanetta Stega, J. Richard Smith, Giuseppe Del Priore

Research output: Chapter in Book/Report/Conference proceedingConference contribution

43 Citations (Scopus)

Abstract

Absolute uterine infertility affects millions of women in the United States and more throughout the world. For instance, each year in the United States about 5,000 hysterectomies are performed in women under the age of 24. In total, nearly 9 million women of reproductive age have had a hysterectomy. Based on fecundity rates, thousands of these women may be candidates for uterus transplantation. An ongoing study enrolling some of these potential recipients onto a uterus transplant "waiting list" has revealed that most of these women have Rokitansky syndrome, hysterectomy secondary to endometriosis, cervical cancer, or compelling personal accounts justifying their candidacy. Fertility restoration by uterus transplantation was derived from fertility preservation research, including the development of the radical trachelectomy, oxygenation and perfusion of the in situ uterus, and work with organ donor networks. A decade of modern animal research set the foundation for this human work. Ongoing experiments include stable, long-term large animal allografts for investigating immunosuppression regimens and other transplantation details. Each of the animal models has contributed to the current knowledge base. Recently, nonhuman primates have been used to further investigate the possibility of human uterus transplantation. Nonhuman primate anatomy is analogous to that of humans with notable exceptions. The first human uterus transplant surgery took place in 2000, but it did not result in a pregnancy. However, taken in total, the magnitude of the intervening work from multiple groups throughout the world has made uterus transplantation a topic for discussion. It may also soon be a reality.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages83-91
Number of pages9
Volume1127
DOIs
StatePublished - Apr 2008
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1127
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Transplants
Ethics
Uterus
Animals
Transplantation
Hysterectomy
Oxygenation
Surgery
Restoration
Allografts
Primates
Fertility
Fertility Preservation
Waiting Lists
Knowledge Bases
Endometriosis
Uterine Cervical Neoplasms
Immunosuppression
Infertility
Experiments

Keywords

  • Uterine factor infertility
  • Uterus transplant

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Nair, A., Stega, J., Smith, J. R., & Del Priore, G. (2008). Uterus transplant: Evidence and ethics. In Annals of the New York Academy of Sciences (Vol. 1127, pp. 83-91). (Annals of the New York Academy of Sciences; Vol. 1127). https://doi.org/10.1196/annals.1434.003

Uterus transplant : Evidence and ethics. / Nair, Anjana; Stega, Jeanetta; Smith, J. Richard; Del Priore, Giuseppe.

Annals of the New York Academy of Sciences. Vol. 1127 2008. p. 83-91 (Annals of the New York Academy of Sciences; Vol. 1127).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nair, A, Stega, J, Smith, JR & Del Priore, G 2008, Uterus transplant: Evidence and ethics. in Annals of the New York Academy of Sciences. vol. 1127, Annals of the New York Academy of Sciences, vol. 1127, pp. 83-91. https://doi.org/10.1196/annals.1434.003
Nair A, Stega J, Smith JR, Del Priore G. Uterus transplant: Evidence and ethics. In Annals of the New York Academy of Sciences. Vol. 1127. 2008. p. 83-91. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1434.003
Nair, Anjana ; Stega, Jeanetta ; Smith, J. Richard ; Del Priore, Giuseppe. / Uterus transplant : Evidence and ethics. Annals of the New York Academy of Sciences. Vol. 1127 2008. pp. 83-91 (Annals of the New York Academy of Sciences).
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