Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease

Dominantly Inherited Alzheimer Network

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET. Methods: FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB-R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross-sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history. Results: Metabolism and perfusion images were spatially correlated. Regional PiB-R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity. Discussion: Hypometabolism estimated by PiB-R1 may provide a measure of brain perfusion without increasing radiation exposure.

Original languageEnglish (US)
Pages (from-to)669-677
Number of pages9
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume10
DOIs
StatePublished - Jan 1 2018

Fingerprint

Positron-Emission Tomography
Alzheimer Disease
Perfusion
Wounds and Injuries
Fluorodeoxyglucose F18
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Dementia
Disease Progression
Cross-Sectional Studies
Biomarkers
Mutation
Brain

Keywords

  • Alzheimer's disease
  • FDG
  • Neuronal injury
  • Perfusion
  • PiB

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease. / Dominantly Inherited Alzheimer Network.

In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, Vol. 10, 01.01.2018, p. 669-677.

Research output: Contribution to journalArticle

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abstract = "Introduction: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET. Methods: FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB-R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross-sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history. Results: Metabolism and perfusion images were spatially correlated. Regional PiB-R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity. Discussion: Hypometabolism estimated by PiB-R1 may provide a measure of brain perfusion without increasing radiation exposure.",
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author = "{Dominantly Inherited Alzheimer Network} and Nelly Joseph-Mathurin and Yi Su and Blazey, {Tyler M.} and Mateusz Jasielec and Andrei Vlassenko and Karl Friedrichsen and Gordon, {Brian A.} and Hornbeck, {Russ C.} and Lisa Cash and Ances, {Beau M.} and Thomas Veale and Cash, {David M.} and Brickman, {Adam M.} and Virginia Buckles and Cairns, {Nigel J.} and Carlos Cruchaga and Alison Goate and Jack, {Clifford R.} and Celeste Karch and William Klunk and Koeppe, {Robert A.} and Marcus, {Daniel S.} and Richard Mayeux and Eric McDade and Noble, {James M.} and John Ringman and Andrew Saykin and Thompson, {Paul M.} and Chengjie Xiong and Morris, {John C.} and Bateman, {Randall J.} and Benzinger, {Tammie L.S.}",
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T1 - Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease

AU - Dominantly Inherited Alzheimer Network

AU - Joseph-Mathurin, Nelly

AU - Su, Yi

AU - Blazey, Tyler M.

AU - Jasielec, Mateusz

AU - Vlassenko, Andrei

AU - Friedrichsen, Karl

AU - Gordon, Brian A.

AU - Hornbeck, Russ C.

AU - Cash, Lisa

AU - Ances, Beau M.

AU - Veale, Thomas

AU - Cash, David M.

AU - Brickman, Adam M.

AU - Buckles, Virginia

AU - Cairns, Nigel J.

AU - Cruchaga, Carlos

AU - Goate, Alison

AU - Jack, Clifford R.

AU - Karch, Celeste

AU - Klunk, William

AU - Koeppe, Robert A.

AU - Marcus, Daniel S.

AU - Mayeux, Richard

AU - McDade, Eric

AU - Noble, James M.

AU - Ringman, John

AU - Saykin, Andrew

AU - Thompson, Paul M.

AU - Xiong, Chengjie

AU - Morris, John C.

AU - Bateman, Randall J.

AU - Benzinger, Tammie L.S.

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N2 - Introduction: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET. Methods: FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB-R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross-sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history. Results: Metabolism and perfusion images were spatially correlated. Regional PiB-R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity. Discussion: Hypometabolism estimated by PiB-R1 may provide a measure of brain perfusion without increasing radiation exposure.

AB - Introduction: 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET. Methods: FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB-R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network. Voxelwise, regional cross-sectional, and longitudinal analyses were done to evaluate the correlation between images and estimate the relationship of the imaging biomarkers with estimated time to disease progression based on family history. Results: Metabolism and perfusion images were spatially correlated. Regional PiB-R1 values and FDG, but not early frames of PiB images, significantly decreased in the mutation carriers with estimated year to onset and with increasing dementia severity. Discussion: Hypometabolism estimated by PiB-R1 may provide a measure of brain perfusion without increasing radiation exposure.

KW - Alzheimer's disease

KW - FDG

KW - Neuronal injury

KW - Perfusion

KW - PiB

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JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

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