Utility of postmortem magnetic resonance imaging in clinical neuropathology

Orest Boyko, S. R. Alston, G. N. Fuller, C. M. Hulette, G. A. Johnson, P. C. Burger

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Over 200 brains were examined by postmortem magnetic resonance imaging to determine the utility of this imaging procedure as an adjunct to the standard postmortem examination of the brain and spinal cord. One unembalmed cadaver was also studied using a conventional 1.5-tesla (T) field-strength unit, and three formalin-fixed sections of the hippocampus were imaged using a high field-strength (7.0-T) prototype imaging system. The postmortem magnetic resonance images proved to be an invaluable aid that complemented the standard pathologic examination of the brain and spinal cord. The compelling advantages of this postmortem radiographic procedure included the three- dimensional aspects of the images; the ability to detect mineral (ie, iron) deposits; small focal lesions such as hemorrhages or infarcts; and the ability to evaluate the extent of cerebral edema. For the same reasons, as well as its archival potential for documenting the topographic distribution of pathologic processes, this technique has great promise for forensic cases. High field-strength (7.0-T) imaging brought the resolution of magnetic resonance to the microscopic level and reaffirmed the potential value of magnetic resonance imaging for diagnostic and investigative studies in which both the histologic and fine radiologic features of lesions are of interest.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalArchives of Pathology and Laboratory Medicine
Volume118
Issue number3
StatePublished - 1994
Externally publishedYes

Fingerprint

Magnetic Resonance Imaging
Spinal Cord
Brain
Magnetic Resonance Spectroscopy
Three-Dimensional Imaging
Brain Edema
Pathologic Processes
Cadaver
Formaldehyde
Minerals
Autopsy
Hippocampus
Iron
Hemorrhage
Neuropathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Boyko, O., Alston, S. R., Fuller, G. N., Hulette, C. M., Johnson, G. A., & Burger, P. C. (1994). Utility of postmortem magnetic resonance imaging in clinical neuropathology. Archives of Pathology and Laboratory Medicine, 118(3), 219-225.

Utility of postmortem magnetic resonance imaging in clinical neuropathology. / Boyko, Orest; Alston, S. R.; Fuller, G. N.; Hulette, C. M.; Johnson, G. A.; Burger, P. C.

In: Archives of Pathology and Laboratory Medicine, Vol. 118, No. 3, 1994, p. 219-225.

Research output: Contribution to journalArticle

Boyko, O, Alston, SR, Fuller, GN, Hulette, CM, Johnson, GA & Burger, PC 1994, 'Utility of postmortem magnetic resonance imaging in clinical neuropathology', Archives of Pathology and Laboratory Medicine, vol. 118, no. 3, pp. 219-225.
Boyko O, Alston SR, Fuller GN, Hulette CM, Johnson GA, Burger PC. Utility of postmortem magnetic resonance imaging in clinical neuropathology. Archives of Pathology and Laboratory Medicine. 1994;118(3):219-225.
Boyko, Orest ; Alston, S. R. ; Fuller, G. N. ; Hulette, C. M. ; Johnson, G. A. ; Burger, P. C. / Utility of postmortem magnetic resonance imaging in clinical neuropathology. In: Archives of Pathology and Laboratory Medicine. 1994 ; Vol. 118, No. 3. pp. 219-225.
@article{19ceadd11f924899bd7366d6fc2e27ca,
title = "Utility of postmortem magnetic resonance imaging in clinical neuropathology",
abstract = "Over 200 brains were examined by postmortem magnetic resonance imaging to determine the utility of this imaging procedure as an adjunct to the standard postmortem examination of the brain and spinal cord. One unembalmed cadaver was also studied using a conventional 1.5-tesla (T) field-strength unit, and three formalin-fixed sections of the hippocampus were imaged using a high field-strength (7.0-T) prototype imaging system. The postmortem magnetic resonance images proved to be an invaluable aid that complemented the standard pathologic examination of the brain and spinal cord. The compelling advantages of this postmortem radiographic procedure included the three- dimensional aspects of the images; the ability to detect mineral (ie, iron) deposits; small focal lesions such as hemorrhages or infarcts; and the ability to evaluate the extent of cerebral edema. For the same reasons, as well as its archival potential for documenting the topographic distribution of pathologic processes, this technique has great promise for forensic cases. High field-strength (7.0-T) imaging brought the resolution of magnetic resonance to the microscopic level and reaffirmed the potential value of magnetic resonance imaging for diagnostic and investigative studies in which both the histologic and fine radiologic features of lesions are of interest.",
author = "Orest Boyko and Alston, {S. R.} and Fuller, {G. N.} and Hulette, {C. M.} and Johnson, {G. A.} and Burger, {P. C.}",
year = "1994",
language = "English (US)",
volume = "118",
pages = "219--225",
journal = "Archives of Pathology and Laboratory Medicine",
issn = "0003-9985",
publisher = "College of American Pathologists",
number = "3",

}

TY - JOUR

T1 - Utility of postmortem magnetic resonance imaging in clinical neuropathology

AU - Boyko, Orest

AU - Alston, S. R.

AU - Fuller, G. N.

AU - Hulette, C. M.

AU - Johnson, G. A.

AU - Burger, P. C.

PY - 1994

Y1 - 1994

N2 - Over 200 brains were examined by postmortem magnetic resonance imaging to determine the utility of this imaging procedure as an adjunct to the standard postmortem examination of the brain and spinal cord. One unembalmed cadaver was also studied using a conventional 1.5-tesla (T) field-strength unit, and three formalin-fixed sections of the hippocampus were imaged using a high field-strength (7.0-T) prototype imaging system. The postmortem magnetic resonance images proved to be an invaluable aid that complemented the standard pathologic examination of the brain and spinal cord. The compelling advantages of this postmortem radiographic procedure included the three- dimensional aspects of the images; the ability to detect mineral (ie, iron) deposits; small focal lesions such as hemorrhages or infarcts; and the ability to evaluate the extent of cerebral edema. For the same reasons, as well as its archival potential for documenting the topographic distribution of pathologic processes, this technique has great promise for forensic cases. High field-strength (7.0-T) imaging brought the resolution of magnetic resonance to the microscopic level and reaffirmed the potential value of magnetic resonance imaging for diagnostic and investigative studies in which both the histologic and fine radiologic features of lesions are of interest.

AB - Over 200 brains were examined by postmortem magnetic resonance imaging to determine the utility of this imaging procedure as an adjunct to the standard postmortem examination of the brain and spinal cord. One unembalmed cadaver was also studied using a conventional 1.5-tesla (T) field-strength unit, and three formalin-fixed sections of the hippocampus were imaged using a high field-strength (7.0-T) prototype imaging system. The postmortem magnetic resonance images proved to be an invaluable aid that complemented the standard pathologic examination of the brain and spinal cord. The compelling advantages of this postmortem radiographic procedure included the three- dimensional aspects of the images; the ability to detect mineral (ie, iron) deposits; small focal lesions such as hemorrhages or infarcts; and the ability to evaluate the extent of cerebral edema. For the same reasons, as well as its archival potential for documenting the topographic distribution of pathologic processes, this technique has great promise for forensic cases. High field-strength (7.0-T) imaging brought the resolution of magnetic resonance to the microscopic level and reaffirmed the potential value of magnetic resonance imaging for diagnostic and investigative studies in which both the histologic and fine radiologic features of lesions are of interest.

UR - http://www.scopus.com/inward/record.url?scp=0028210209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028210209&partnerID=8YFLogxK

M3 - Article

VL - 118

SP - 219

EP - 225

JO - Archives of Pathology and Laboratory Medicine

JF - Archives of Pathology and Laboratory Medicine

SN - 0003-9985

IS - 3

ER -