Vaccine strategies: Optimising outcomes

Karin Hardt, Paolo Bonanni, Susan King, Jose Ignacio Santos, Mostafa El-Hodhod, Gregory Zimet, Scott Preiss

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Successful immunisation programmes generally result from high vaccine effectiveness and adequate uptake of vaccines. In the development of new vaccination strategies, the structure and strength of the local healthcare system is a key consideration. In high income countries, existing infrastructures are usually used, while in less developed countries, the capacity for introducing new vaccines may need to be strengthened, particularly for vaccines administered beyond early childhood, such as the measles or human papillomavirus (HPV) vaccine. Reliable immunisation service funding is another important factor and low income countries often need external supplementary sources of finance. Many regions also obtain support in generating an evidence base for vaccination via initiatives created by organisations including World Health Organization (WHO), the Pan American Health Organization (PAHO), the Agence de Médecine Préventive and the Sabin Vaccine Institute. Strong monitoring and surveillance mechanisms are also required. An example is the efficient and low-cost approaches for measuring the impact of the hepatitis B control initiative and evaluating achievement of goals that have been established in the WHO Western Pacific region. A review of implementation strategies reveals differing degrees of success. For example, in the Americas, PAHO advanced a measles-mumps-rubella vaccine strategy, targeting different population groups in mass, catch-up and follow-up vaccination campaigns. This has had much success but coverage data from some parts of the region suggest that children are still not receiving all appropriate vaccines, highlighting problems with local service infrastructures. Stark differences in coverage levels are also observed among high income countries, as is the case with HPV vaccine implementation in the USA versus the UK and Australia, reflecting differences in delivery settings. Experience and research have shown which vaccine strategies work well and the factors that encourage success, which often include strong support from government and healthcare organisations, as well as tailored, culturally-appropriate local approaches to optimise outcomes.

Original languageEnglish (US)
Pages (from-to)6691-6699
Number of pages9
JournalVaccine
Volume34
Issue number52
DOIs
StatePublished - Dec 20 2016

Fingerprint

Vaccines
vaccines
Pan American Health Organization
Papillomavirus Vaccines
Immunization Programs
Vaccination
Oral Poliovirus Vaccine
income
Organizations
Measles-Mumps-Rubella Vaccine
Papillomaviridae
Delivery of Health Care
vaccination
World Health Organization
infrastructure
health services
Measles
Hepatitis B
immunization
Population Groups

Keywords

  • Coverage
  • Implementation
  • National immunisation programme
  • Planning
  • Strategy
  • Vaccination

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Hardt, K., Bonanni, P., King, S., Santos, J. I., El-Hodhod, M., Zimet, G., & Preiss, S. (2016). Vaccine strategies: Optimising outcomes. Vaccine, 34(52), 6691-6699. https://doi.org/10.1016/j.vaccine.2016.10.078

Vaccine strategies : Optimising outcomes. / Hardt, Karin; Bonanni, Paolo; King, Susan; Santos, Jose Ignacio; El-Hodhod, Mostafa; Zimet, Gregory; Preiss, Scott.

In: Vaccine, Vol. 34, No. 52, 20.12.2016, p. 6691-6699.

Research output: Contribution to journalArticle

Hardt, K, Bonanni, P, King, S, Santos, JI, El-Hodhod, M, Zimet, G & Preiss, S 2016, 'Vaccine strategies: Optimising outcomes', Vaccine, vol. 34, no. 52, pp. 6691-6699. https://doi.org/10.1016/j.vaccine.2016.10.078
Hardt K, Bonanni P, King S, Santos JI, El-Hodhod M, Zimet G et al. Vaccine strategies: Optimising outcomes. Vaccine. 2016 Dec 20;34(52):6691-6699. https://doi.org/10.1016/j.vaccine.2016.10.078
Hardt, Karin ; Bonanni, Paolo ; King, Susan ; Santos, Jose Ignacio ; El-Hodhod, Mostafa ; Zimet, Gregory ; Preiss, Scott. / Vaccine strategies : Optimising outcomes. In: Vaccine. 2016 ; Vol. 34, No. 52. pp. 6691-6699.
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